V
Vyacheslav Amstislavskiy
Researcher at Max Planck Society
Publications - 29
Citations - 23910
Vyacheslav Amstislavskiy is an academic researcher from Max Planck Society. The author has contributed to research in topics: Transcriptome & Gene. The author has an hindex of 19, co-authored 28 publications receiving 17351 citations.
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Journal ArticleDOI
Erratum: Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome (Cancer Cell (2019) 36(2) (123–138.e10), (S1535610819302983), (10.1016/j.ccell.2019.06.007))
M Labuhn,Kelly J. Perkins,Sören Matzk,Leila N. Varghese,Catherine Garnett,Elli Papaemmanuil,Marlen Metzner,Alison Kennedy,Vyacheslav Amstislavskiy,Thomas Risch,Raj Bhayadia,David Samulowski,David Cruz Hernandez,Bilyana Stoilova,Valentina Iotchkova,Udo Oppermann,C Scheer,Kenichi Yoshida,Adrian Schwarzer,Jeffrey W. Taub,John D. Crispino,Mitchell J. Weiss,Yasuhide Hayashi,Takashi Taga,Etsuro Ito,Seishi Ogawa,Dirk Reinhardt,Marie-Laure Yaspo,Peter J. Campbell,Irene Roberts,Stefan N. Constantinescu,Paresh Vyas,Dirk Heckl,Jan-Henning Klusmann +33 more
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Comparative analysis and modeling of the severity of steatohepatitis in DDC-treated mouse strains
Vikash Pandey,Marc Sultan,Karl Kashofer,Meryem Ralser,Vyacheslav Amstislavskiy,Julia Starmann,Ingrid Osprian,Christina Grimm,Hendrik Hache,Marie-Laure Yaspo,Holger Sültmann,Michael Trauner,Helmut Denk,Kurt Zatloukal,Hans Lehrach,Christoph Wierling +15 more
TL;DR: This study identifies AA/eicosanoid metabolism as highly perturbed in DDC-induced mice and demonstrates that a dynamic model can be used for qualitative prediction of metabolic changes based on transcriptomics data in a disease-related context.
Journal ArticleDOI
The direction of cross affects obesity after puberty in male but not female offspring
Stefan Kärst,Danny Arends,Sebastian Heise,Jan Trost,Marie-Laure Yaspo,Vyacheslav Amstislavskiy,Thomas Risch,Hans Lehrach,Gudrun A. Brockmann +8 more
TL;DR: Parent-of-origin effects during gametogenesis and/or fetal development in an obese mother epigenetically modify the transcription of genes that lead to enhanced fatty acid synthesis and impair β-oxidation in the liver of male, but not female F1 offspring.
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RNA Sequencing of Human Peripheral Blood Cells Indicates Upregulation of Immune-Related Genes in Huntington's Disease
Miguel A. Andrade-Navarro,Katja Mühlenberg,Eike Jakob Spruth,Nancy Mah,Adrián González-López,Tommaso Andreani,Jenny Russ,Matthew R. Huska,Enrique M. Muro,Jean-Fred Fontaine,Vyacheslav Amstislavskiy,Alexei Soldatov,Wilfried Nietfeld,Erich E. Wanker,Josef Priller,Josef Priller +15 more
TL;DR: A gene expression signature consistent with dysregulation of immune-related functions and inflammatory response in peripheral blood from HD cases vs. controls is detected, which may reflect the immune pathology associated with the disease.
Journal ArticleDOI
Impact of congenital cytomegalovirus infection on transcriptomes from archived dried blood spots in relation to long-term clinical outcome.
Roberta Rovito,Hans-Jörg Warnatz,Szymon M. Kielbasa,Hailiang Mei,Vyacheslav Amstislavskiy,Ramon Arens,Marie-Laure Yaspo,Hans Lehrach,Aloys C.M. Kroes,Jelle J. Goeman,Ann C. T. M. Vossen +10 more
TL;DR: In this paper, the authors determined whole blood transcriptomes in relation to cCMV, CMV viral load and LTI development at 6 years of age by using RNA isolated from neonatal dried blood spots (DBS) stored at room temperature for 8 years.