W
W. M. Linehan
Researcher at National Institutes of Health
Publications - 101
Citations - 11813
W. M. Linehan is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Renal cell carcinoma & Kidney. The author has an hindex of 53, co-authored 101 publications receiving 11355 citations.
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Journal ArticleDOI
Mutations of the VHL tumour suppressor gene in renal carcinoma
James R. Gnarra,K. Tory,Yongkai Weng,Laura S. Schmidt,Ming-Hui Wei,Haiyan I. Li,Farida Latif,S. Liu,F. Chen,Fuh Mei Duh,Irina A. Lubensky,D. R. Duan,C. Florence,Rudy Pozzatti,M. M. Walther,Neil H. Bander,H.B. Grossman,Hiltrud Brauch,S. Pomer,James D. Brooks,William B. Isaacs,Michael I. Lerman,Berton Zbar,W. M. Linehan +23 more
TL;DR: The identification of VHL mutations in a majority of localized and advanced sporadic renal carcinomas and in a second form of hereditary renal carcinoma indicates that the VHL gene plays a critical part in the origin of this malignancy.
Journal ArticleDOI
Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene
James R. Gnarra,S Zhou,Marsha J. Merrill,Joseph Wagner,Anton Krumm,E Papavassiliou,Edward H. Oldfield,Richard D. Klausner,W. M. Linehan +8 more
TL;DR: Results suggest that V HL regulates VEGF expression at a post-transcriptional level and that VHL inactivation in target cells causes a loss of VEGf suppression, leading to formation of a vascular stroma.
Journal ArticleDOI
Novel mutations of the MET proto-oncogene in papillary renal carcinomas.
Laura S. Schmidt,Kerstin Junker,Noboru Nakaigawa,T. Kinjerski,Gregor Weirich,M. Miller,Irina A. Lubensky,Hartmut P. H. Neumann,Hiltrud Brauch,Jochen Decker,Cathy D. Vocke,J. A. Brown,Robert B. Jenkins,Stéphane Richard,Ulf S.R. Bergerheim,Bernard Gerrard,Michael Dean,W. M. Linehan,Berton Zbar +18 more
TL;DR: The low frequency of MET mutations in noninherited papillary renal carcinomas (PRC) suggests that non inherited PRC may develop by a different mechanism than hereditary papillary kidneys carcinoma.
Journal ArticleDOI
Cyclophosphamide-Induced Cystitis and Bladder Cancer in Patients with Wegener Granulomatosis
Cheryl Talar-Williams,Y M Hijazi,M. M. Walther,W. M. Linehan,Claire W. Hallahan,Irina A. Lubensky,Gail S. Kerr,Gary S. Hoffman,Anthony S. Fauci,Michael C. Sneller +9 more
TL;DR: The incidence, clinical manifestations, and natural history of cyclophosphamide-mediated urotoxicity in a cohort of patients with Wegener granulomatosis are described and recommendations for surveillance are discussed.
Journal ArticleDOI
von Hippel-Lindau disease: genetic, clinical, and imaging features.
TL;DR: The major events that led to the discovery of the gene for VHL are described and recent developments in the magnetic resonance Imaging, computed tomographic, and ultrasound findings of this entity are familiarized with.