Showing papers by "Wafaa S. Hamama published in 2020"
8 citations
18 Dec 2020
7 citations
TL;DR: An overview of 3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one (DHA) chemistry can be found in this article.
Abstract:
The following review article provides an overview of DHA chemistry, with specific
confirmation based on major historical developments and progress mainly made over
the last two decenniums. It is our hope this review serves as a valuable treasure to those
interested in the 3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one (DHA) chemistry, and helps
impact future advancements.
6 citations
TL;DR: This article provided an overview of the chemistry and biological importance of the cationic chalcophene derivatives (furans, thiophenes, and selenophenes) and discussed the proposed mechanisms of some interesting synthetic routes and linking structure features to biological activities.
Abstract:
The present study provides an overview of the chemistry and biological importance
of the cationic chalcophene derivatives (furans, thiophenes and selenophenes). The
summarized literature survey includes synthetic methods, reactivity and biological activities
of aryl/hetarylchalcophenes that have been reported mainly from 2001 to 2019 focusing
on monochalcophenes. A discussion demonstrating the proposed mechanisms of some
interesting synthetic routes and linking structure features to biological activities is presented.
These classes of compounds including cationic chalcophenes possess antiproliferative,
antimicrobial and antiprotozoal activities. This review highlights recent advances
for arylchalcophene derivatives and may contribute to the design and structure optimization
of new chalcophene derivatives in the future.
6 citations
5 citations
TL;DR: Taken together, these promising anticancer candidates are effective at very low concentrations and safe to normal cells, and most probably work through arresting the cell cycle, and therefore, they deserve further investigations.
Abstract: Three thienylpicolinamidine derivatives 4a–c were prepared from their corresponding picolinonitriles 3a–c on treatment with lithium trimethylsilylamide, LiN(TMS)2, followed by a de-protection step using ethanol/HCl (gas).
5 citations
TL;DR: A survey of the recent progress in the chemistry of 4,6-dimethyl-3-amino-3H-pyrazolo[3,4-b]pyridine can be found in this article.
3 citations
TL;DR: In this paper, five thienylnicotinamidine derivatives 5a-e were prepared from their corresponding nicotinonitriles 3a−e on treatment with lithium trimethylsilylamide [LiN(TMS)2] followed by hydrolysis using ethan...
3 citations
TL;DR: The authors summarizes the most common synthetic routes as applied to the preparation of many modern pharmaceutical compounds categorized as 2-amino-3-cyano-quinoxaline 1, 4-dioxide and its derivat...
3 citations