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Bob Argiropoulos
Researcher at Alberta Children's Hospital
Publications - 46
Citations - 2831
Bob Argiropoulos is an academic researcher from Alberta Children's Hospital. The author has contributed to research in topics: Myeloid leukemia & Leukemia. The author has an hindex of 21, co-authored 46 publications receiving 2586 citations. Previous affiliations of Bob Argiropoulos include University of Calgary & University of British Columbia.
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Journal ArticleDOI
Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype
Daniel T. Starczynowski,Florian Kuchenbauer,Bob Argiropoulos,Sandy Sung,Ryan D. Morin,Andrew L Muranyi,Martin Hirst,Donna E. Hogge,Marco A. Marra,Richard A. Wells,Rena Buckstein,Wan L. Lam,R. Keith Humphries,Aly Karsan +13 more
TL;DR: Deletes chromosome 5q and identifies Toll–interleukin-1 receptor domain–containing adaptor protein (TIRAP) and tumor necrosis factor receptor–associated factor-6 (TRAF6) as respective targets of these miRNAs.
Journal ArticleDOI
Hox genes in hematopoiesis and leukemogenesis
TL;DR: It is proposed that Hox-dependent pathways are closely linked to the self-renewal program crucial to the origin and function of leukemic stem cells.
Journal ArticleDOI
In-depth characterization of the microRNA transcriptome in a leukemia progression model
Florian Kuchenbauer,Ryan D. Morin,Bob Argiropoulos,Oleh Petriv,Malachi Griffith,Michael Heuser,Eric Yung,Jessica Piper,Allen Delaney,Anna-Liisa Prabhu,Yongjun Zhao,Helen McDonald,Thomas Zeng,Martin Hirst,Carl L. Hansen,Marco A. Marra,R. Keith Humphries +16 more
TL;DR: The potential for miRNA-mediated release of oncogenes that facilitates leukemic progression from the preleukemic to leukemia inducing state is revealed and the finding of extensive sequence variations (isomiRs) for almost all miRNA and miRNA species adds additional complexity to the miRNA transcriptome.
Journal ArticleDOI
Disruption of the ASTN2/TRIM32 locus at 9q33.1 is a risk factor in males for autism spectrum disorders, ADHD and other neurodevelopmental phenotypes
Anath C. Lionel,Kristiina Tammimies,Kristiina Tammimies,Andrea K. Vaags,Jill A. Rosenfeld,Joo Wook Ahn,Daniele Merico,Abdul Noor,Cassandra K. Runke,Vamsee Pillalamarri,Melissa T. Carter,Matthew J. Gazzellone,Bhooma Thiruvahindrapuram,Christina Fagerberg,Lone W. Laulund,Giovanna Pellecchia,Sylvia Lamoureux,Charu Deshpande,Jill Clayton-Smith,Ann C White,Susan Leather,John Trounce,H. Melanie Bedford,Eli Hatchwell,Peggy S. Eis,Ryan K. C. Yuen,Susan Walker,Mohammed Uddin,Michael T. Geraghty,Michael T. Geraghty,Sarah M. Nikkel,Sarah M. Nikkel,Eva M Tomiak,Bridget A. Fernandez,Noam Soreni,Jennifer Crosbie,Paul D. Arnold,Russell Schachar,Wendy Roberts,Andrew D. Paterson,Joyce So,Peter Szatmari,Christina Chrysler,Marc Woodbury-Smith,R. Brian Lowry,Lonnie Zwaigenbaum,Divya Mandyam,John Wei,Jeffrey R. MacDonald,Jennifer L. Howe,Thomas Nalpathamkalam,Zhuozhi Wang,Daniel Tolson,David S Cobb,Timothy Wilks,Mark J Sorensen,Patricia I. Bader,Yu An,Bai-Lin Wu,Bai-Lin Wu,Bai-Lin Wu,Sebastiano A. Musumeci,Corrado Romano,Diana Postorivo,Anna Maria Nardone,Matteo Della Monica,Gioacchino Scarano,Leonardo Zoccante,Francesca Novara,Orsetta Zuffardi,Roberto Ciccone,Vincenzo Antona,Massimo Carella,Leopoldo Zelante,Pietro Cavalli,Carlo Poggiani,Ugo Cavallari,Bob Argiropoulos,Bob Argiropoulos,Bob Argiropoulos,Judy Chernos,Judy Chernos,Judy Chernos,Charlotte Brasch-Andersen,Marsha Speevak,Marco Fichera,Caroline Mackie Ogilvie,Yiping Shen,Yiping Shen,Yiping Shen,Jennelle C. Hodge,Michael E. Talkowski,Dimitri J. Stavropoulos,Christian R. Marshall,Stephen W. Scherer +94 more
TL;DR: The 3'-terminal ASTN2 deletions were significantly enriched compared with controls in males with NDDs, but not in females, and new light is shed on the role of the astrotactins in psychopathology and their interplay in human neurodevelopment.
Journal ArticleDOI
MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML.
Michael Heuser,Bob Argiropoulos,Florian Kuchenbauer,Eric Yung,Jessica Piper,Stephen Fung,Richard F. Schlenk,Konstanze Döhner,Tanja Hinrichsen,Cornelia Rudolph,Axel Schambach,Christopher Baum,Brigitte Schlegelberger,Hartmut Döhner,Arnold Ganser,R. Keith Humphries +15 more
TL;DR: It is demonstrated using retroviral gene transfer and bone marrow transplantation that MN1 overexpression rapidly induces lethal AML in mice, and MN1 is a unique oncogene in hematopoiesis that both promotes proliferation/self-renewal and blocks differentiation, and may become useful as a predictive marker in AML treatment.