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Wei Xu
Researcher at Fudan University
Publications - 48
Citations - 4531
Wei Xu is an academic researcher from Fudan University. The author has contributed to research in topics: Ebola virus & Coronavirus. The author has an hindex of 23, co-authored 48 publications receiving 2891 citations. Previous affiliations of Wei Xu include Pasteur Institute & Indiana University.
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Journal ArticleDOI
Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19.
TL;DR: Recent research advance in the structure, function and development of antivirus drugs targeting the spike (S) protein of SARS-CoV-2 is highlighted.
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Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion.
Shuai Xia,Meiqin Liu,Chao Wang,Wei Xu,Qiaoshuai Lan,Siliang Feng,Feifei Qi,Linlin Bao,Lanying Du,Shuwen Liu,Chuan Qin,Fei Sun,Zhengli Shi,Yun Zhu,Shibo Jiang,Shibo Jiang,Lu Lu +16 more
TL;DR: EK1C4 was the most potent fusion inhibitor against SARS-CoV-2 S protein-mediated membrane fusion and pseudovirus infection with IC50s of 1.3 and 15.8 nM, about 241- and 149-fold more potent than the original EK1 peptide, respectively.
Journal ArticleDOI
Ebola Virus VP24 Targets a Unique NLS Binding Site on Karyopherin Alpha 5 to Selectively Compete with Nuclear Import of Phosphorylated STAT1.
Wei Xu,Megan R. Edwards,Dominika Borek,Alicia R. Feagins,Anuradha Mittal,Joshua B. Alinger,Kayla N. Berry,Benjamin Yen,Jennifer Hamilton,Tom J. Brett,Rohit V. Pappu,Daisy W. Leung,Christopher F. Basler,Gaya K. Amarasinghe +13 more
TL;DR: Ebola virus VP24 protein counters cell-intrinsic innate immunity by selectively targeting PY-STAT1 nuclear import while leaving the transport of other cargo that may be required for viral replication unaffected.
Journal ArticleDOI
SIRT5 Desuccinylates and Activates Pyruvate Kinase M2 to Block Macrophage IL-1β Production and to Prevent DSS-Induced Colitis in Mice
Fang Wang,Ke Wang,Wei Xu,Shimin Zhao,Dan Ye,Yi Wang,Ying Xu,L Zhou,Yiwei Chu,Cuiping Zhang,Xue Qin,Pengyuan Yang,Hongxiu Yu +12 more
TL;DR: The findings reveal a mechanism by which SIRT5 suppresses the pro-inflammatory response in macrophages at least in part by regulating PKM2 succinylation, activity, and function.
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A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry.
Yunkai Zhu,Fei Feng,Gaowei Hu,Yuyan Wang,Yin Yu,Yuanfei Zhu,Wei Xu,Xia Cai,Zhiping Sun,Wendong Han,Rong Ye,Di Qu,Qiang Ding,Xinxin Huang,Hongjun Chen,Youhua Xie,Qiliang Cai,Zhenghong Yuan,Rong Zhang +18 more
TL;DR: In this paper, the authors performed a genome-wide CRISPR screen and identified several endosomal entry-specific regulators, including host factors regulating the surface expression of angiotensin-converting enzyme 2 (ACE2) for SARS-CoV-2.