Y
Yuyan Wang
Researcher at Fudan University
Publications - 41
Citations - 1173
Yuyan Wang is an academic researcher from Fudan University. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 10, co-authored 31 publications receiving 456 citations. Previous affiliations of Yuyan Wang include Fudan University Shanghai Medical College.
Papers
More filters
Journal ArticleDOI
Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids.
Bing Zhao,Chao Ni,Ran Gao,Yuyan Wang,Li Yang,Jinsong Wei,Ting Lv,Jianqing Liang,Qisheng Zhang,Wei Xu,Youhua Xie,Xiaoyue Wang,Zhenghong Yuan,Junbo Liang,Rong Zhang,Xinhua Lin +15 more
TL;DR: The use of human organoids are reported as a tool to investigate the SARS-CoV-2 infection and virus-induced tissue damage ex vivo at the cellular and molecular levels.
Journal ArticleDOI
A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry.
Yunkai Zhu,Fei Feng,Gaowei Hu,Yuyan Wang,Yin Yu,Yuanfei Zhu,Wei Xu,Xia Cai,Zhiping Sun,Wendong Han,Rong Ye,Di Qu,Qiang Ding,Xinxin Huang,Hongjun Chen,Youhua Xie,Qiliang Cai,Zhenghong Yuan,Rong Zhang +18 more
TL;DR: In this paper, the authors performed a genome-wide CRISPR screen and identified several endosomal entry-specific regulators, including host factors regulating the surface expression of angiotensin-converting enzyme 2 (ACE2) for SARS-CoV-2.
Posted ContentDOI
Functional and Genetic Analysis of Viral Receptor ACE2 Orthologs Reveals Broad Potential Host Range of SARS-CoV-2
Yinghui Liu,Gaowei Hu,Yuyan Wang,Xiaomin Zhao,Fansen Ji,Wenlin Ren,Mingli Gong,Xiaohui Ju,Changhe Li,Junxian Hong,Yuanfei Zhu,Xia Cai,Jianping Wu,Xun Lan,Youhua Xie,Xinquan Wang,Zhenghong Yuan,Rong Zhang,Qiang Ding +18 more
TL;DR: It is demonstrated that ACE2 from a remarkably broad range of species can facilitate SARS-CoV-2 entry and might be distributed much more widely than previously recognized, underscoring the necessity to monitor susceptible hosts to prevent future outbreaks.
Journal ArticleDOI
Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2.
Yunqing Gu,Jun Cao,Xin-Yu Zhang,Hai Gao,Yuyan Wang,Jia Wang,Juan He,Xiaoyi Jiang,Jinlan Zhang,Guanghui Shen,Jie Yang,Xichen Zheng,Gaowei Hu,Yuanfei Zhu,Shujuan Du,Yunkai Zhu,Rong Zhang,Jianqing Xu,Fei Lan,Di Qu,Guoliang Xu,Guoliang Xu,Yun Zhao,Dong Gao,Youhua Xie,Min Luo,Zhigang Lu +26 more
TL;DR: In this paper, the authors performed genomic receptor profiling to screen 5054 human membrane proteins individually for interaction with the SARS-CoV-2 capsid spike (S) protein.
Journal ArticleDOI
A novel cell culture system modeling the SARS-CoV-2 life cycle.
Xiaohui Ju,Yunkai Zhu,Yuyan Wang,Jingrui Li,Jiaxing Zhang,Mingli Gong,Wenlin Ren,Sai Li,Jin Zhong,Linqi Zhang,Qiangfeng Cliff Zhang,Rong Zhang,Qiang Ding +12 more
TL;DR: Wang et al. as mentioned in this paper developed a biosafety level 2 (BSL-2) cell culture system for production of transcription and replication-competent SARS-CoV-2 virus-like-particles (trVLP).