H
Haoyu Chen
Researcher at The Chinese University of Hong Kong
Publications - 216
Citations - 5640
Haoyu Chen is an academic researcher from The Chinese University of Hong Kong. The author has contributed to research in topics: Medicine & Optical coherence tomography. The author has an hindex of 32, co-authored 175 publications receiving 4609 citations. Previous affiliations of Haoyu Chen include Sun Yat-sen University & Moran Eye Center.
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Journal ArticleDOI
A Variant of the HTRA1 Gene Increases Susceptibility to Age-Related Macular Degeneration
Zhenglin Yang,Nicola J. Camp,Hui Sun,Zongzhong Tong,Daniel Gibbs,D. Joshua Cameron,Haoyu Chen,Yu Zhao,Erik G. Pearson,Xi Li,Jeremy Chien,Andrew T. DeWan,Jennifer Harmon,Paul S. Bernstein,Viji Shridhar,Norman A. Zabriskie,Josephine Hoh,Kimberly A. Howes,Kang Zhang +18 more
TL;DR: A single-nucleotide polymorphism in the promoter region of HTRA1 is the most likely causal variant for AMD at 10q26 and is estimated to confer a population attributable risk of 49.3%.
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Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability
Christopher A. Jones,Nyall London,Haoyu Chen,Kye Won Park,Kye Won Park,Dominique Sauvaget,Rebecca A. Stockton,Joshua D. Wythe,Wonhee Suh,Wonhee Suh,Frederic Larrieu-Lahargue,Yoh Suke Mukouyama,Per Lindblom,Per Lindblom,Pankaj Seth,Antonio E. Frias,Naoyuki Nishiya,Naoyuki Nishiya,Mark H. Ginsberg,Holger Gerhardt,Kang Zhang,Dean Y. Li +21 more
TL;DR: A previously unknown function for Robo receptors in stabilizing the vasculature is defined and it is suggested that activating Robo4 may have broad therapeutic application in diseases characterized by excessive angiogenesis and/or vascular leak.
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Retrospective analysis of the possibility of predicting the COVID-19 outbreak from Internet searches and social media data, China, 2020.
TL;DR: The peak of Internet searches and social media data about the coronavirus disease 2019 (COVID-19) outbreak occurred 10–14 days earlier than the peak of daily incidences in China and the lag correlations showed a maximum correlation of 0.89 in all correlations.
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Toll-like Receptor 3 and Geographic Atrophy in Age-Related Macular Degeneration
Zhenglin Yang,Charity A. Stratton,Peter J. Francis,Mark E. Kleinman,Perciliz L. Tan,Daniel Gibbs,Zongzhong Tong,Haoyu Chen,Haoyu Chen,Ryan Constantine,Xian Yang,Xian Yang,Yuhong Chen,Yuhong Chen,Jiexi Zeng,Jiexi Zeng,Lisa Davey,Xiang Ma,V. S. Hau,Chi Wang,Jennifer Harmon,Jeanette Buehler,Erik G. Pearson,Shrena Patel,Yuuki Kaminoh,Scott Watkins,Ling Luo,Norman A. Zabriskie,Paul S. Bernstein,Wongil Cho,Andrea L. Schwager,David R. Hinton,Michael L. Klein,Sara C. Hamon,Emily Simmons,Beifeng Yu,Betsy Campochiaro,Janet S. Sunness,Janet S. Sunness,Peter A. Campochiaro,Lynn B. Jorde,Giovanni Parmigiani,Donald J. Zack,Nicholas Katsanis,Jayakrishna Ambati,Kang Zhang,Kang Zhang,Kang Zhang +47 more
TL;DR: The results suggest a role of viral dsRNA in the development of geographic atrophy and point to the potential toxic effects of short-interfering-RNA therapies in the eye.
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Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice
Zhenglin Yang,Yali Chen,Concepción Lillo,Jeremy Chien,Zhengya Yu,Michel Michaelides,Michel Michaelides,Martin Klein,Kim A. Howes,Yang Li,Yuuki Kaminoh,Haoyu Chen,Chao Zhao,Yuhong Chen,Youssef T. Al-Sheikh,Goutam Karan,Denis Corbeil,Pascal Escher,Shin Kamaya,Chunmei Li,Samantha Johnson,Jeanne M. Frederick,Yu Zhao,Changguan Wang,D. Joshua Cameron,Wieland B. Huttner,Daniel F. Schorderet,F. L. Munier,Anthony T. Moore,Anthony T. Moore,David G. Birch,Wolfgang Baehr,David M. Hunt,David S. Williams,David S. Williams,Kang Zhang,Kang Zhang +36 more
TL;DR: Immunoprecipitation studies showed that PROM1 interacted with protocadherin 21 (PCDH21), a photoreceptor-specific cadherin, and with actin filaments, both of which play critical roles in disk membrane morphogenesis, and indicate a possible role forPROM1 and PCDH21 in macular degeneration.