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Weiwei Shan
Researcher at Fudan University
Publications - 24
Citations - 1312
Weiwei Shan is an academic researcher from Fudan University. The author has contributed to research in topics: Endometrial cancer & Endometrial hyperplasia. The author has an hindex of 11, co-authored 20 publications receiving 968 citations. Previous affiliations of Weiwei Shan include University of Pennsylvania.
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Journal ArticleDOI
Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers
Xiaohui Yan,Xiaohui Yan,Zhongyi Hu,Yi Feng,Xiaowen Hu,Jiao Yuan,Sihai Dave Zhao,Youyou Zhang,Lu Yang,Lu Yang,Weiwei Shan,Weiwei Shan,Qun He,Lingling Fan,Lingling Fan,Lana E. Kandalaft,Lana E. Kandalaft,Janos L. Tanyi,Chunsheng Li,Chao-Xing Yuan,Dongmei Zhang,Dongmei Zhang,Huiqing Yuan,Keqin Hua,Yiling Lu,Dionyssios Katsaros,Qihong Huang,Kathleen T. Montone,Yi Fan,George Coukos,Jeff Boyd,Anil K. Sood,Timothy R. Rebbeck,Gordon B. Mills,Chi V. Dang,Lin Zhang +35 more
TL;DR: A comprehensive analysis of lncRNA alterations at transcriptional, genomic, and epigenetic levels in 5,037 human tumor specimens across 13 cancer types from The Cancer Genome Atlas suggests that the expression and dysregulation of lNCRNAs are highly cancer type specific compared with protein-coding genes.
Journal ArticleDOI
Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer
Youyou Zhang,Qun He,Zhongyi Hu,Yi Feng,Lingling Fan,Zhaoqing Tang,Jiao Yuan,Weiwei Shan,Chunsheng Li,Xiaowen Hu,Janos L. Tanyi,Yi Fan,Qihong Huang,Kathleen T. Montone,Chi V. Dang,Lin Zhang +15 more
TL;DR: It is found that LINP1 enhances repair of DNA double-strand breaks by serving as a scaffold linking Ku80 and DNA-PKcs, thereby coordinating the NHEJ pathway.
Journal ArticleDOI
Repression of BET activity sensitizes homologous recombination-proficient cancers to PARP inhibition.
Lu Yang,Lu Yang,Youyou Zhang,Weiwei Shan,Weiwei Shan,Zhongyi Hu,Jiao Yuan,Jingjiang Pi,Yueying Wang,Lingling Fan,Lingling Fan,Zhaoqing Tang,Chunsheng Li,Xiaowen Hu,Janos L. Tanyi,Yi Fan,Qihong Huang,Kathleen T. Montone,Chi V. Dang,Lin Zhang +19 more
TL;DR: The authors found that BET inhibitors suppress homologous recombination, inducing the functional defect that sensitizes tumors to PARP inhibitors, and found that inhibition or depletion of BET proteins impairs transcription of BRCA1 and RAD51, two genes essential for HR.
Journal ArticleDOI
Infiltrating Macrophages Induce ERα Expression Through an IL17A-mediated Epigenetic Mechanism to Sensitize Endometrial Cancer Cells to Estrogen
Chengcheng Ning,Bingying Xie,Bingying Xie,Lin Zhang,Chunsheng Li,Weiwei Shan,Bingyi Yang,Xuezhen Luo,Chao Gu,Qizhi He,Hongyan Jin,Xiaojun Chen,Zhenbo Zhang,Youji Feng +13 more
TL;DR: Findings show how cytokines produced by infiltrating macrophages in the endometrial microenvironment can induce epigenetic upregulation of ERα expression, which in turn sensitizesendometrial cells to estrogen stimulation.
Journal ArticleDOI
Treatment efficiency of comprehensive hysteroscopic evaluation and lesion resection combined with progestin therapy in young women with endometrial atypical hyperplasia and endometrial cancer
Bingyi Yang,Yuhui Xu,Qin Zhu,Liying Xie,Weiwei Shan,Chengcheng Ning,Bingying Xie,Yue Shi,Xuezhen Luo,Hongwei Zhang,Xiaojun Chen +10 more
TL;DR: Comprehensive hysteroscopic evaluation and lesion resection plus progestin therapy seem to be an effective and safe fertility sparing therapy for patients with EAH or EEC who wished to preserve their fertility.