Y
Youyou Zhang
Researcher at University of Pennsylvania
Publications - 19
Citations - 1785
Youyou Zhang is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Long non-coding RNA & RNA. The author has an hindex of 12, co-authored 17 publications receiving 1367 citations.
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Journal ArticleDOI
Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers
Xiaohui Yan,Xiaohui Yan,Zhongyi Hu,Yi Feng,Xiaowen Hu,Jiao Yuan,Sihai Dave Zhao,Youyou Zhang,Lu Yang,Lu Yang,Weiwei Shan,Weiwei Shan,Qun He,Lingling Fan,Lingling Fan,Lana E. Kandalaft,Lana E. Kandalaft,Janos L. Tanyi,Chunsheng Li,Chao-Xing Yuan,Dongmei Zhang,Dongmei Zhang,Huiqing Yuan,Keqin Hua,Yiling Lu,Dionyssios Katsaros,Qihong Huang,Kathleen T. Montone,Yi Fan,George Coukos,Jeff Boyd,Anil K. Sood,Timothy R. Rebbeck,Gordon B. Mills,Chi V. Dang,Lin Zhang +35 more
TL;DR: A comprehensive analysis of lncRNA alterations at transcriptional, genomic, and epigenetic levels in 5,037 human tumor specimens across 13 cancer types from The Cancer Genome Atlas suggests that the expression and dysregulation of lNCRNAs are highly cancer type specific compared with protein-coding genes.
Journal ArticleDOI
A Functional Genomic Approach Identifies FAL1 as an Oncogenic Long Noncoding RNA that Associates with BMI1 and Represses p21 Expression in Cancer
Xiaowen Hu,Yi Feng,Dongmei Zhang,Dongmei Zhang,Sihai Dave Zhao,Zhongyi Hu,Joel Greshock,Youyou Zhang,Lu Yang,Lu Yang,Xiaomin Zhong,Xiaomin Zhong,Li-Ping Wang,Stephanie Jean,Chunsheng Li,Qihong Huang,Dionyssios Katsaros,Kathleen T. Montone,Janos L. Tanyi,Yiling Lu,Jeff Boyd,Katherine L. Nathanson,Hongzhe Li,Gordon B. Mills,Lin Zhang +24 more
TL;DR: This work has identified an oncogene, focally amplified lncRNA on chromosome 1 (FAL1), whose copy number and expression are correlated with outcomes in ovarian cancer, and FAL1-specific siRNAs significantly inhibit tumor growth in vivo.
Journal ArticleDOI
Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer
Youyou Zhang,Qun He,Zhongyi Hu,Yi Feng,Lingling Fan,Zhaoqing Tang,Jiao Yuan,Weiwei Shan,Chunsheng Li,Xiaowen Hu,Janos L. Tanyi,Yi Fan,Qihong Huang,Kathleen T. Montone,Chi V. Dang,Lin Zhang +15 more
TL;DR: It is found that LINP1 enhances repair of DNA double-strand breaks by serving as a scaffold linking Ku80 and DNA-PKcs, thereby coordinating the NHEJ pathway.
Journal ArticleDOI
Repression of BET activity sensitizes homologous recombination-proficient cancers to PARP inhibition.
Lu Yang,Lu Yang,Youyou Zhang,Weiwei Shan,Weiwei Shan,Zhongyi Hu,Jiao Yuan,Jingjiang Pi,Yueying Wang,Lingling Fan,Lingling Fan,Zhaoqing Tang,Chunsheng Li,Xiaowen Hu,Janos L. Tanyi,Yi Fan,Qihong Huang,Kathleen T. Montone,Chi V. Dang,Lin Zhang +19 more
TL;DR: The authors found that BET inhibitors suppress homologous recombination, inducing the functional defect that sensitizes tumors to PARP inhibitors, and found that inhibition or depletion of BET proteins impairs transcription of BRCA1 and RAD51, two genes essential for HR.
Journal ArticleDOI
Integrated Analysis of Genetic Ancestry and Genomic Alterations across Cancers
Jiao Yuan,Zhongyi Hu,Brandon A. Mahal,Sihai Dave Zhao,Kevin H. Kensler,Jingjiang Pi,Xiaowen Hu,Youyou Zhang,Yueying Wang,Junjie Jiang,Chunsheng Li,Xiaomin Zhong,Kathleen T. Montone,Guoqiang Guan,Janos L. Tanyi,Yi Fan,Xiaowei Xu,Mark A. Morgan,Meixiao Long,Yuzhen Zhang,Rugang Zhang,Anil K. Sood,Timothy R. Rebbeck,Chi V. Dang,Chi V. Dang,Lin Zhang +25 more
TL;DR: The genetic ancestry of The Cancer Genome Atlas patients was estimated, and a pan-cancer analysis on the influence of genetic ancestry on genomic alterations was performed, providing insight into genomic contribution to cancer disparities.