L
Lu Yang
Researcher at University of Pennsylvania
Publications - 24
Citations - 1109
Lu Yang is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Medicine & Computer science. The author has an hindex of 5, co-authored 6 publications receiving 911 citations. Previous affiliations of Lu Yang include Guangxi University & Sichuan University.
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Journal ArticleDOI
Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers
Xiaohui Yan,Xiaohui Yan,Zhongyi Hu,Yi Feng,Xiaowen Hu,Jiao Yuan,Sihai Dave Zhao,Youyou Zhang,Lu Yang,Lu Yang,Weiwei Shan,Weiwei Shan,Qun He,Lingling Fan,Lingling Fan,Lana E. Kandalaft,Lana E. Kandalaft,Janos L. Tanyi,Chunsheng Li,Chao-Xing Yuan,Dongmei Zhang,Dongmei Zhang,Huiqing Yuan,Keqin Hua,Yiling Lu,Dionyssios Katsaros,Qihong Huang,Kathleen T. Montone,Yi Fan,George Coukos,Jeff Boyd,Anil K. Sood,Timothy R. Rebbeck,Gordon B. Mills,Chi V. Dang,Lin Zhang +35 more
TL;DR: A comprehensive analysis of lncRNA alterations at transcriptional, genomic, and epigenetic levels in 5,037 human tumor specimens across 13 cancer types from The Cancer Genome Atlas suggests that the expression and dysregulation of lNCRNAs are highly cancer type specific compared with protein-coding genes.
Journal ArticleDOI
A Functional Genomic Approach Identifies FAL1 as an Oncogenic Long Noncoding RNA that Associates with BMI1 and Represses p21 Expression in Cancer
Xiaowen Hu,Yi Feng,Dongmei Zhang,Dongmei Zhang,Sihai Dave Zhao,Zhongyi Hu,Joel Greshock,Youyou Zhang,Lu Yang,Lu Yang,Xiaomin Zhong,Xiaomin Zhong,Li-Ping Wang,Stephanie Jean,Chunsheng Li,Qihong Huang,Dionyssios Katsaros,Kathleen T. Montone,Janos L. Tanyi,Yiling Lu,Jeff Boyd,Katherine L. Nathanson,Hongzhe Li,Gordon B. Mills,Lin Zhang +24 more
TL;DR: This work has identified an oncogene, focally amplified lncRNA on chromosome 1 (FAL1), whose copy number and expression are correlated with outcomes in ovarian cancer, and FAL1-specific siRNAs significantly inhibit tumor growth in vivo.
Journal ArticleDOI
Repression of BET activity sensitizes homologous recombination-proficient cancers to PARP inhibition.
Lu Yang,Lu Yang,Youyou Zhang,Weiwei Shan,Weiwei Shan,Zhongyi Hu,Jiao Yuan,Jingjiang Pi,Yueying Wang,Lingling Fan,Lingling Fan,Zhaoqing Tang,Chunsheng Li,Xiaowen Hu,Janos L. Tanyi,Yi Fan,Qihong Huang,Kathleen T. Montone,Chi V. Dang,Lin Zhang +19 more
TL;DR: The authors found that BET inhibitors suppress homologous recombination, inducing the functional defect that sensitizes tumors to PARP inhibitors, and found that inhibition or depletion of BET proteins impairs transcription of BRCA1 and RAD51, two genes essential for HR.
Journal ArticleDOI
Oncogenic RAS Regulates Long Noncoding RNA Orilnc1 in Human Cancer.
Dongmei Zhang,Dongmei Zhang,Gao Zhang,Xiaowen Hu,Lawrence Wu,Yi Feng,Sidan He,Youyou Zhang,Zhongyi Hu,Lu Yang,Lu Yang,Tian Tian,Weiting Xu,Zhi Wei,Yiling Lu,Keith T. Flaherty,Xiaomin Zhong,Xiaomin Zhong,Gordon B. Mills,Phyllis A. Gimotty,Xiaowei Xu,Meenhard Herlyn,Lin Zhang +22 more
TL;DR: Using a custom-designed lncRNA microarray, Orilnc1 is identified as a genetic target of RAS that is critical for RAS oncogenicity and may serve as a therapeutic target in RAS/RAF-driven cancers.
Journal ArticleDOI
Risk-Based Multi-Objective Optimization of Distributed Generation Based on GPSO-BFA Algorithm
TL;DR: This paper establishes a comprehensive set of risk and economic indexes by modeling the randomness and uncertainty of DG outputs and proposes a risk-based multi-objective optimal allocation model to optimize the placement and configuration of DGs and provide a reliable and cost-effective system.