S
Sihai Dave Zhao
Researcher at University of Illinois at Urbana–Champaign
Publications - 66
Citations - 2403
Sihai Dave Zhao is an academic researcher from University of Illinois at Urbana–Champaign. The author has contributed to research in topics: Nonparametric statistics & Medicine. The author has an hindex of 20, co-authored 55 publications receiving 1938 citations. Previous affiliations of Sihai Dave Zhao include University of Pennsylvania & French Institute of Health and Medical Research.
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Journal ArticleDOI
Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers
Xiaohui Yan,Xiaohui Yan,Zhongyi Hu,Yi Feng,Xiaowen Hu,Jiao Yuan,Sihai Dave Zhao,Youyou Zhang,Lu Yang,Lu Yang,Weiwei Shan,Weiwei Shan,Qun He,Lingling Fan,Lingling Fan,Lana E. Kandalaft,Lana E. Kandalaft,Janos L. Tanyi,Chunsheng Li,Chao-Xing Yuan,Dongmei Zhang,Dongmei Zhang,Huiqing Yuan,Keqin Hua,Yiling Lu,Dionyssios Katsaros,Qihong Huang,Kathleen T. Montone,Yi Fan,George Coukos,Jeff Boyd,Anil K. Sood,Timothy R. Rebbeck,Gordon B. Mills,Chi V. Dang,Lin Zhang +35 more
TL;DR: A comprehensive analysis of lncRNA alterations at transcriptional, genomic, and epigenetic levels in 5,037 human tumor specimens across 13 cancer types from The Cancer Genome Atlas suggests that the expression and dysregulation of lNCRNAs are highly cancer type specific compared with protein-coding genes.
Journal ArticleDOI
A Functional Genomic Approach Identifies FAL1 as an Oncogenic Long Noncoding RNA that Associates with BMI1 and Represses p21 Expression in Cancer
Xiaowen Hu,Yi Feng,Dongmei Zhang,Dongmei Zhang,Sihai Dave Zhao,Zhongyi Hu,Joel Greshock,Youyou Zhang,Lu Yang,Lu Yang,Xiaomin Zhong,Xiaomin Zhong,Li-Ping Wang,Stephanie Jean,Chunsheng Li,Qihong Huang,Dionyssios Katsaros,Kathleen T. Montone,Janos L. Tanyi,Yiling Lu,Jeff Boyd,Katherine L. Nathanson,Hongzhe Li,Gordon B. Mills,Lin Zhang +24 more
TL;DR: This work has identified an oncogene, focally amplified lncRNA on chromosome 1 (FAL1), whose copy number and expression are correlated with outcomes in ovarian cancer, and FAL1-specific siRNAs significantly inhibit tumor growth in vivo.
Journal ArticleDOI
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases
Yun Li,Jin Li,Sihai Dave Zhao,Sihai Dave Zhao,Jonathan P. Bradfield,Frank D. Mentch,S. Melkorka Maggadottir,Cuiping Hou,Debra J. Abrams,Diana Chang,Feng Gao,Yiran Guo,Zhi Wei,John Connolly,Christopher J. Cardinale,Marina Bakay,Joseph T. Glessner,Dong Li,Charlly Kao,Kelly A. Thomas,Haijun Qiu,Rosetta M. Chiavacci,Cecilia E. Kim,Fengxiang Wang,James Snyder,Marylyn D Richie,Berit Flatø,Øystein Førre,Lee A. Denson,Susan D. Thompson,Mara L. Becker,Stephen L. Guthery,Anna Latiano,Elena E. Perez,Elena S. Resnick,Richard K Russell,David C. Wilson,Mark S. Silverberg,Vito Annese,Benedicte A. Lie,Marilynn Punaro,Marla Dubinsky,Dimitri S. Monos,Caterina Strisciuglio,Annamaria Staiano,Erasmo Miele,Subra Kugathasan,Justine A. Ellis,Jane E Munro,Kathleen E. Sullivan,Carol Wise,Helen Chapel,Charlotte Cunningham-Rundles,Struan F.A. Grant,Jordan S. Orange,Patrick M. A. Sleiman,Edward M. Behrens,Anne M. Griffiths,Jack Satsangi,Terri H. Finkel,Alon Keinan,Eline T. Luning Prak,Constantin Polychronakos,Robert N. Baldassano,Hongzhe Li,Brendan J. Keating,Hakon Hakonarson +66 more
TL;DR: Network and protein-interaction analyses demonstrated converging roles for the signaling pathways of type 1, 2 and 17 helper T cells (TH1, TH2 and TH17), JAK-STAT, interferon and interleukin in multiple autoimmune diseases.
Journal ArticleDOI
Principled sure independence screening for Cox models with ultra-high-dimensional covariates
Sihai Dave Zhao,Yi Li +1 more
TL;DR: This paper theoretically justify a principled method for reducing dimensionality in the analysis of censored data by selecting only the important covariates and presents simulation results and applies the proposed procedure to analyze the multiple myeloma study.
Journal ArticleDOI
Integrated Analysis of Genetic Ancestry and Genomic Alterations across Cancers
Jiao Yuan,Zhongyi Hu,Brandon A. Mahal,Sihai Dave Zhao,Kevin H. Kensler,Jingjiang Pi,Xiaowen Hu,Youyou Zhang,Yueying Wang,Junjie Jiang,Chunsheng Li,Xiaomin Zhong,Kathleen T. Montone,Guoqiang Guan,Janos L. Tanyi,Yi Fan,Xiaowei Xu,Mark A. Morgan,Meixiao Long,Yuzhen Zhang,Rugang Zhang,Anil K. Sood,Timothy R. Rebbeck,Chi V. Dang,Chi V. Dang,Lin Zhang +25 more
TL;DR: The genetic ancestry of The Cancer Genome Atlas patients was estimated, and a pan-cancer analysis on the influence of genetic ancestry on genomic alterations was performed, providing insight into genomic contribution to cancer disparities.