H
Hiroyuki Inuzuka
Researcher at Beth Israel Deaconess Medical Center
Publications - 121
Citations - 7607
Hiroyuki Inuzuka is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Ubiquitin ligase & Kinase. The author has an hindex of 44, co-authored 107 publications receiving 6509 citations. Previous affiliations of Hiroyuki Inuzuka include Kagawa University & Emory University.
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Journal ArticleDOI
SCF FBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction
Hiroyuki Inuzuka,Shavali Shaik,Ichiro Onoyama,Darning Gao,Alan Tseng,Richard S. Maser,Bo Zhai,Lixin Wan,Alejandro Gutierrez,Alan W. Lau,Yonghong Xiao,Amanda L. Christie,Jon C. Aster,Jeffrey Settleman,Steven P. Gygi,Andrew L. Kung,Thomas Look,Keiichi I. Nakayama,Ronald A. DePinho,Wenyi Wei +19 more
TL;DR: It is shown that the E3 ubiquitin ligase SCFFBW7 (a SKP1–cullin-1–F-box complex that contains FBW7 as the F-box protein) governs cellular apoptosis by targeting MCL1, a pro-survival BCL2 family member, for ubiquitylation and destruction in a manner that depends on phosphorylation by glycogen synthase kinase 3.
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Roles of F-box proteins in cancer
TL;DR: Additional genetic and mechanistic studies will help to define the role of each F-box protein in tumorigenesis, thereby paving the road for the rational design of F- box protein-targeted anticancer therapies.
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Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus
Pengda Liu,Michael J. Begley,Wojciech Michowski,Hiroyuki Inuzuka,Miriam Bracha Ginzberg,Daming Gao,Peiling Tsou,Wenjian Gan,Antonella Papa,Byeong Mo Kim,Lixin Wan,Amrik Singh,Bo Zhai,Min Yuan,Zhiwei Wang,Steven P. Gygi,Tae Ho Lee,Kun Ping Lu,Alex Toker,Pier Paolo Pandolfi,John M. Asara,Marc W. Kirschner,Piotr Sicinski,Lewis C. Cantley,Wenyi Wei +24 more
TL;DR: The results of this study show Akt S477/T479 phosphorylation to be an essential layer of the Akt activation mechanism to regulate its physiological functions, thereby providing a new mechanistic link between aberrant cell cycle progression and Akt hyperactivation in cancer.
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STO-609, a Specific Inhibitor of the Ca2+/Calmodulin-dependent Protein Kinase Kinase
Hiroshi Tokumitsu,Hiroyuki Inuzuka,Yumi Ishikawa,Masahiko Ikeda,Ikutaro Saji,Ryoji Kobayashi +5 more
TL;DR: Results indicate that STO-609 is a selective and cell-permeable inhibitor of CaM-KK and that it may be a useful tool for evaluating the physiological significance of the CaM/calmodulin-dependent protein kinase kinase pathway in vivo as well as in vitro.
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mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR.
Daming Gao,Hiroyuki Inuzuka,Meng Kwang Marcus Tan,Hidefumi Fukushima,Jason W. Locasale,Pengda Liu,Lixin Wan,Bo Zhai,Y. Rebecca Chin,Shavali Shaik,Costas A. Lyssiotis,Steven P. Gygi,Alex Toker,Lewis C. Cantley,John M. Asara,J. Wade Harper,Wenyi Wei +16 more
TL;DR: This work describes an mTOR-dependent phosphorylation-driven pathway for DEPTOR destruction via SCF(βTrCP) and reveals a positive feedback loop involving mTOR and CKI-dependent turnover of its inhibitor, DEPTor, suggesting that misregulation of the DEptOR destruction pathway might contribute to aberrant activation of mTOR in disease.