W
William Breuer
Researcher at Hebrew University of Jerusalem
Publications - 82
Citations - 6404
William Breuer is an academic researcher from Hebrew University of Jerusalem. The author has contributed to research in topics: Transferrin & Deferiprone. The author has an hindex of 39, co-authored 81 publications receiving 6107 citations. Previous affiliations of William Breuer include Utrecht University & French Institute of Health and Medical Research.
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Journal ArticleDOI
Labile plasma iron in iron overload: redox activity and susceptibility to chelation
Breno Pannia Espósito,William Breuer,Pornpan Sirankapracha,Pensri Pootrakul,Chaim Hershko,Z. Ioav Cabantchik +5 more
TL;DR: Oral treatment of patients with deferiprone (L1) raised plasma NTBI due to iron mobilization but did not lead to LPI appearance, indicating that L1-chelated iron in plasma was not redox active, and oral L1 treatment eliminated LPI in patients.
Journal ArticleDOI
Fluorescence analysis of the labile iron pool of mammalian cells.
TL;DR: The method provides a simple, noninvasive tool for on-line monitoring of cytosolic iron under normal and abnormal conditions of cell iron supply and for assessing the dynamics of intracellular iron in living cells.
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Iron Acquired from Transferrin by K562 Cells Is Delivered into a Cytoplasmic Pool of Chelatable Iron(II)
TL;DR: It is concluded that after iron is translocated from the endosomes, it is maintained in the cytosol as a transit pool of chelatable iron(II), which implicates the intracellular operation of vigorous reductive mechanisms.
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Ineffective erythropoiesis in β-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin
Sara Gardenghi,Maria F. Marongiu,Pedro Ramos,Pedro Ramos,Ella Guy,Laura Breda,Amy Chadburn,Yi Fang Liu,Ninette Amariglio,Gideon Rechavi,Eliezer A. Rachmilewitz,William Breuer,Z. Ioav Cabantchik,Diedra M. Wrighting,Nancy C. Andrews,Maria de Sousa,Maria de Sousa,Patricia J. Giardina,Robert W. Grady,Stefano Rivella +19 more
TL;DR: It is shown, for the first time, that tissue and cellular iron distribution are abnormal and different in th3/+ and th3/th3 mice, and that transfusion therapy can rescue mice affected by beta-thalassemia major and modify both the absorption and distribution of iron.
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LPI-labile plasma iron in iron overload
TL;DR: In this article, the authors compared deferrioxamine and deferiprone in terms of their efficacy in minimizing daily exposure to labile plasma iron (LPI) in thalassemia major/intermedia patients with transfusional iron overload and other forms of hemosiderosis.