William G. Nelson

TL;DR: A hypothesized critical role for GSTP1 inactivation in the earliest steps of prostatic carcinogenesis provides several attractive opportunities for prostate cancer prevention strategies, including restoration of GSTP 1 function, compensation for inadequate GSTP2 activity, and abrogation or attenuation of genome-damaging stresses.

TL;DR: In this article, DNA methyltransferase 1 (DNMT1) expression is dysregulated in breast cancer without a concomitant increase in DNMT1 mRNA or proliferative fraction.

TL;DR: It is concluded that testicular germ cell tumors are derived in most cases from IGCNU cells that have undergone developmentally programmed 5mC erasure and that the degree of subsequent de novo methylation is most closely related to the differentiation state of the neoplastic cells.

TL;DR: An evolutionary argument is presented that attempts to relate a high-fat diet, with its potential for generating oxidative DNA damage, to the species selectivity of prostate cancer and an argument based on preliminary studies indicating that chronic inflammation and the associated increase in cell turnover in the setting of increased oxidative stress may help to account for the organSelectivity of genitourinary carcinomas.

TL;DR: It is found thatDNMT1 protein levels were elevated in breast cancer tissues and in MCF-7 breast cancer cells relative to normal human mammary epithelial cells (HMECs) without a concomitant increase in DNMT1 mRNA or proliferative fraction.