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William G. Nelson
Researcher at Johns Hopkins University School of Medicine
Publications - 302
Citations - 32149
William G. Nelson is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Prostate cancer & Prostate. The author has an hindex of 93, co-authored 292 publications receiving 30356 citations. Previous affiliations of William G. Nelson include New York University & Johns Hopkins University.
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Journal ArticleDOI
Pathological and molecular mechanisms of prostate carcinogenesis: implications for diagnosis, detection, prevention, and treatment.
Angelo M. De Marzo,Theodore L. DeWeese,Elizabeth A. Platz,Alan K. Meeker,Masashi Nakayama,Jonathan I. Epstein,William B. Isaacs,William G. Nelson +7 more
TL;DR: The subject of inflammation and prostate cancer is reviewed as part of a “chronic epithelial injury” hypothesis of prostate carcinogenesis, and the somatic genome and phenotypic changes characteristic of prostate cancer cells are reviewed.
Journal ArticleDOI
Chronic Inflammation in Benign Prostate Tissue Is Associated with High-Grade Prostate Cancer in the Placebo Arm of the Prostate Cancer Prevention Trial
Bora Gurel,M. Scott Lucia,Ian M. Thompson,Phyllis J. Goodman,Catherine M. Tangen,Alan R. Kristal,Howard L. Parnes,Ashraful Hoque,Scott M. Lippman,Siobhan Sutcliffe,Sarah B. Peskoe,Charles G. Drake,William G. Nelson,Angelo M. De Marzo,Elizabeth A. Platz +14 more
TL;DR: Inflammation, most of which was chronic, was common in benign prostate tissue, and was positively associated with prostate cancer, especially high grade, and suggests an avenue for prevention by mitigating intraprostatic inflammation.
Journal Article
CG island methylation changes near the GSTP1 gene in prostatic carcinoma cells detected using the polymerase chain reaction: a new prostate cancer biomarker.
TL;DR: This GSTP1 CG island DNA methylation assay, which targets a somatic genome change present in most prostate cancer cells but not in normal cells, may serve as a new molecular diagnosis and staging tool to aid in prostate cancer detection and treatment.
Journal ArticleDOI
Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inflicted by low-level radiation.
Theodore L. DeWeese,Jennifer M. Shipman,Nicole A. Larrier,Nicola M. Buckley,La Creis R. Kidd,John D. Groopman,Richard G. Cutler,Hein te Riele,William G. Nelson +8 more
TL;DR: This article showed that mice deficient in DNA mismatch repair responded abnormally when exposed to low levels of ionizing radiation, a stress known to generate oxidative DNA damage, which may contribute to the increased cancer risk characteristic of hereditary nonpolyposis colorectal cancer syndrome.
Journal Article
Reversal of GSTP1 CpG Island Hypermethylation and Reactivation of π-Class Glutathione S-Transferase (GSTP1) Expression in Human Prostate Cancer Cells by Treatment with Procainamide
Xiaohui Lin,Kekule Asgari,Mathew J. Putzi,Wesley R. Gage,Xiang Yu,Brian Cornblatt,Arunima Kumar,Steven Piantadosi,Theodore L. DeWeese,Angelo M. De Marzo,William G. Nelson +10 more
TL;DR: The drug procainamide, a nonnucleoside inhibitor of DNA methyltransferases, reversed GSTP1 CpG island hypermethylation and restored GSTP 1 expression in LNCaP human PCA cells propagated in vitro or in vivo as xenograft tumors in athymic nude mice.