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William G. Nelson
Researcher at Johns Hopkins University School of Medicine
Publications - 302
Citations - 32149
William G. Nelson is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Prostate cancer & Prostate. The author has an hindex of 93, co-authored 292 publications receiving 30356 citations. Previous affiliations of William G. Nelson include New York University & Johns Hopkins University.
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Journal ArticleDOI
Global 5-Hydroxymethylcytosine Levels Are Profoundly Reduced in Multiple Genitourinary Malignancies
Enrico Munari,Alcides Chaux,Ajay Vaghasia,Diana Taheri,Diana Taheri,Sarah Karram,Stephania M. Bezerra,Nilda Diana Gonzalez Roibon,William G. Nelson,Srinivasan Yegnasubramanian,George J. Netto,Michael C. Haffner +11 more
TL;DR: The substantial tumor specific loss of 5hmC, particularly in clear cell renal cell carcinomas and urothelial cell carcinoma, suggests that alterations in pathways involved in establishing and maintaining 5hm C levels might be very common in cancer and could potentially be exploited for diagnosis and treatment.
Journal ArticleDOI
Prostate Cancer Epigenetics: From Basic Mechanisms to Clinical Implications
TL;DR: Interestingly, alterations in the prostate cancer epigenetic cityscape can be highly recurrent, a facet that can be exploited for development of biomarkers and potentially as therapeutic targets.
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Intraprostatic inflammation is positively associated with serum PSA in men with PSA <4 ng ml −1 , normal DRE and negative for prostate cancer
M H Umbehr,Bora Gurel,Bora Gurel,Teemu J. Murtola,Siobhan Sutcliffe,Sarah B. Peskoe,Catherine M. Tangen,Phyllis J. Goodman,Ian M. Thompson,Scott M. Lippman,M.S. Lucia,Howard L. Parnes,Charles G. Drake,William G. Nelson,A. M. De Marzo,Elizabeth A. Platz +15 more
TL;DR: In men without clinical suspicion of prostate cancer, greater overall inflammation, luminal and intraepithelial acute inflammation and stromal and intraepsithelial chronic inflammation were associated with higher serum PSA.
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The association of urinary cadmium with sex steroid hormone concentrations in a general population sample of US adult men.
Andy Menke,Eliseo Guallar,Eliseo Guallar,Meredith S. Shiels,Sabine Rohrmann,Shehzad Basaria,Nader Rifai,William G. Nelson,Elizabeth A. Platz +8 more
TL;DR: Urinary cadmium levels were not associated with sex steroid hormone concentrations in a large nationally representative sample of US men.
Journal ArticleDOI
Prostate cancer prevention agent development: Criteria and pipeline for candidate chemoprevention agents.
William G. Nelson,George Wilding +1 more
TL;DR: In this review, 10 criteria for prostate cancer chemoprevention agent development are offered and the pipeline of new prostate cancerChemopreventions drug candidates is considered.