W
William G. Nelson
Researcher at Johns Hopkins University School of Medicine
Publications - 302
Citations - 32149
William G. Nelson is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Prostate cancer & Prostate. The author has an hindex of 93, co-authored 292 publications receiving 30356 citations. Previous affiliations of William G. Nelson include New York University & Johns Hopkins University.
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Journal ArticleDOI
Molecular Pathology of High-Grade Prostatic Intraepithelial Neoplasia: Challenges and Opportunities.
Levent Trabzonlu,Ibrahim Kulac,Qizhi Zheng,Jessica L. Hicks,Michael C. Haffner,William G. Nelson,Karen S. Sfanos,Onur Ertunc,Tamara L. Lotan,Christopher M. Heaphy,Alan K. Meeker,Srinivasan Yegnasubramanian,Angelo M. De Marzo +12 more
TL;DR: Current understanding of the morphological and molecular pathological features of prostate cancer precursor lesions are reviewed and it is suggested that some fraction of such lesions that are morphologically consistent with HGPIN may actually be invasive carcinomas masquerading as HGPIn-a state that the authors term "postinvasive intraepithelial carcinoma" (PIC).
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Die GSTP1-CpG-Insel-Hypermethylierung als molekularer Marker des Prostatakarzinoms
TL;DR: The role of GSTP1 CpG island hypermethylation in prostatic cancers is evaluated and its possible role as a molecular biomarker of prostate cancer is discussed.
Journal ArticleDOI
Association of serum inorganic phosphate with sex steroid hormones and vitamin D in a nationally representative sample of men.
Wahyu Wulaningsih,M. Van Hemelrijck,Karl Michaëlsson,Norma Kanarek,William G. Nelson,Joachim H. Ix,Elizabeth A. Platz,Sabine Rohrmann +7 more
TL;DR: The findings suggest a weak link among sex hormones, vitamin D, and Pi in men, and the observed effects of race/ethnicity and vitamin D indicate a complex association involving various regulators of Pi homeostasis.
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Humanizing π-class glutathione S-transferase regulation in a mouse model alters liver toxicity in response to acetaminophen overdose.
Matthew P. Vaughn,Debika Biswal Shinohara,Nicole Castagna,Jessica Hicks,George J. Netto,Angelo M. De Marzo,Traci J. Speed,Zachery R. Reichert,Bernard Kwabi-Addo,Colin J. Henderson,C. Roland Wolf,Srinivasan Yegnasubramanian,William G. Nelson +12 more
TL;DR: Rec recapitulating human π-class GST expression, hGSTP1+mGstp1/2−/− mice may better model human drug and xenobiotic toxicology.
Journal ArticleDOI
Resistance to androgen receptor signaling inhibition does not necessitate development of neuroendocrine prostate cancer
W. Nathaniel Brennen,W. Nathaniel Brennen,Yezi Zhu,Ilsa Coleman,Susan L. Dalrymple,Lizamma Antony,Radhika A. Patel,Brian Hanratty,Roshan Chikarmane,Alan K. Meeker,Alan K. Meeker,S. Lilly Zheng,Jody E. Hooper,Jun Luo,Angelo M. De Marzo,Angelo M. De Marzo,Eva Corey,Jianfeng Xu,Srinivasan Yegnasubramanian,Michael C. Haffner,Michael C. Haffner,Peter S. Nelson,William G. Nelson,William G. Nelson,William B. Isaacs,John T. Isaacs,John T. Isaacs +26 more
TL;DR: In this article, molecular, cell, and tumor biology analyses were performed on 23 xenografts derived from patients with PC, recapitulating the full spectrum of genetic alterations proposed to drive NE differentiation.