W
William G. Nelson
Researcher at Johns Hopkins University School of Medicine
Publications - 302
Citations - 32149
William G. Nelson is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Prostate cancer & Prostate. The author has an hindex of 93, co-authored 292 publications receiving 30356 citations. Previous affiliations of William G. Nelson include New York University & Johns Hopkins University.
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Journal ArticleDOI
GSTA1 expression in normal, preneoplastic, and neoplastic human prostate tissue.
J. Kellogg Parsons,Chad P. Nelson,Wesley R. Gage,William G. Nelson,Thomas W. Kensler,Angelo M. De Marzo +5 more
TL;DR: It is postulated that this increase in GSTP1 expression in PIA occurs in response to increased oxidative stress, and the expression of another major class of GST, GSTA1, in the human prostate was examined.
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Transcription-induced DNA double strand breaks: both oncogenic force and potential therapeutic target?
Michael C. Haffner,Angelo M. De Marzo,Alan K. Meeker,William G. Nelson,Srinivasan Yegnasubramanian +4 more
TL;DR: It is proposed that, in hormone-dependent tumors like breast and prostate cancers, a hormone-cycling therapy, in combination with topoisomerase II poisons or inhibitors of the DNA repair components PARP1 and DNA-PK, could overwhelm cancer cells with transcription-associated DSBs.
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Genome-wide comparison of the transcriptomes of highly enriched normal and chronic myeloid leukemia stem and progenitor cell populations.
Jonathan M. Gerber,Jessica L. Gucwa,David M. Esopi,Meltem Gürel,Michael C. Haffner,Milada S. Vala,William G. Nelson,Richard J. Jones,Srinivasan Yegnasubramanian +8 more
TL;DR: Governing-wide transcriptome analysis of highly refined CML and normal stem and progenitor cell populations was performed to identify novel targets for the eradication of CML LSCs using exon microarrays, identifying 97 genes that were differentially expressed in CML versus normalstem and progensitor cells.
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Sensitivity of human prostatic carcinoma cell lines to low dose rate radiation exposure
TL;DR: Radiation-associated pertubations in replicative cell cycle progression were not dominant determinants of low dose rate radiation killing efficacy in human prostate cancer cell lines in vitro.
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Serum sex steroid hormones and lower urinary tract symptoms in Third National Health and Nutrition Examination Survey (NHANES III).
Sabine Rohrmann,William G. Nelson,Nader Rifai,Norma Kanarek,Shehzad Basaria,Konstantinos K. Tsilidis,Ellen Smit,Edward Giovannucci,Edward Giovannucci,Elizabeth A. Platz +9 more
TL;DR: In this cross-sectional study representative of older U.S. men, circulating AAG, a metabolite of dihydrotestosterone, and estradiol were associated with an increased risk of having LUTS.