William G. Nelson

TL;DR: Compared with clonogenic survival of cells which are isogeneic except for p53 functional status, it is found that loss of a G1 checkpoint in mammalian cells is not associated with increased sensitivity to the lethal effects of ionizing radiation or a topoisomerase I inhibitor, camptothecin, and indicates thatIncreased sensitivity to DNA-damaging agents is not necessarily a defining feature of a mammalian cell cycle checkpoint.

TL;DR: A model for CHROMOSOME STRUCTURE and a model for DNA topoisomerases associated with the NUCLEAR MATRIX are presented.

TL;DR: Quantitation of GSTP1 methylation accurately discriminates between normal hyperplastic tissue and prostatic carcinoma in small samples of prostate tissue and may augment the standard pathologic/histologic assessment of the prostate.

TL;DR: Low free and bioavailable testosterone concentrations in the normal range were associated with diabetes, independent of adiposity, and data suggest that low androgen levels may be a risk factor for diabetes in men.

TL;DR: The hypothesis that atrophic epithelium in a subset of PIA lesions may lead to high-grade PIN and/or adenocarcinoma is supported, because these atrophic lesions are so prevalent and extensive, even though only a small subset contains this somatic DNA alteration.