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William L. Crosby
Researcher at University of Windsor
Publications - 72
Citations - 13089
William L. Crosby is an academic researcher from University of Windsor. The author has contributed to research in topics: Gene & Arabidopsis. The author has an hindex of 35, co-authored 72 publications receiving 12536 citations. Previous affiliations of William L. Crosby include National Republican Congressional Committee & University of Saskatchewan.
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Journal ArticleDOI
Genome-Wide Insertional Mutagenesis of Arabidopsis thaliana
Jose M. Alonso,Anna Stepanova,Thomas J. Leisse,Christopher J. Kim,Huaming Chen,Paul Shinn,Denise K. Stevenson,Justin Zimmerman,Pascual Barajas,Rosa Cheuk,Carmelita Gadrinab,Collen Heller,Albert Jeske,Eric Koesema,Cristina C. Meyers,Holly Parker,Lance Prednis,Yasser Ansari,Nathan Choy,Hashim Deen,Michael Geralt,Nisha Hazari,Emily Hom,Meagan Karnes,Celene Mulholland,Ral Ndubaku,Ian Thomas Schmidt,Plinio Guzmán,Laura Aguilar-Henonin,Markus Schmid,Detlef Weigel,David E. Carter,Trudy Marchand,Eddy Risseeuw,Debra Brogden,Albana Zeko,William L. Crosby,Charles C. Berry,Joseph R. Ecker +38 more
TL;DR: Genome-wide analysis of the distribution of integration events revealed the existence of a large integration site bias at both the chromosome and gene levels, and insertion mutations were identified in genes that are regulated in response to the plant hormone ethylene.
Journal ArticleDOI
Isolation of high affinity human antibodies directly from large synthetic repertoires.
Andrew D. Griffiths,S C Williams,Oliver Hartley,I M Tomlinson,Peter M. Waterhouse,William L. Crosby,Roland E. Kontermann,Peter T. Jones,N. M. Low,T. J. Allison +9 more
TL;DR: This work created highly diverse repertoires of heavy and light chains entirely in vitro from a bank of human V gene segments and generated a large synthetic repertoire of Fab fragments displayed on filamentous phage to help dissect the contributions of biological mechanisms and structural features governing V gene usage in vivo.
Journal ArticleDOI
The SCFCOI1 Ubiquitin-Ligase Complexes Are Required for Jasmonate Response in Arabidopsis
Linghui Xu,Fuquan Liu,Esther Lechner,Pascal Genschik,William L. Crosby,Hong Ma,Wen Peng,Dafang Huang,Daoxin Xie +8 more
TL;DR: It is demonstrated that COI1 associates physically with AtCUL1, AtRbx1, and either of the Arabidopsis Skp1-like proteins ASK1 or ASK2 to assemble ubiquitin-ligase complexes, which are designated SCF(COI1), and that the axr1 and coi1 mutations display a synergistic genetic interaction in the double mutant.
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Identification of an SCF ubiquitin–ligase complex required for auxin response in Arabidopsis thaliana
William M. Gray,William M. Gray,J. Carlos del Pozo,J. Carlos del Pozo,Loni Walker,Lawrence Hobbie,Lawrence Hobbie,Eddy Risseeuw,Travis W. Banks,William L. Crosby,Ming Yang,Hong Ma,Mark Estelle,Mark Estelle +13 more
TL;DR: In Arabidopsis, auxin response is dependent on a ubiquitin-ligase (E3) complex called SCFTIR1, which provides new support for a model in which auxin action depends on the regulated proteolysis of repressor proteins.
Journal ArticleDOI
Interactions of the COP9 Signalosome with the E3 Ubiquitin Ligase SCF TIR1 in Mediating Auxin Response
Claus Schwechheimer,Giovanna Serino,Judy Callis,William L. Crosby,Svetlana Lyapina,Raymond J. Deshaies,William M. Gray,Mark Estelle,Xing Wang Deng +8 more
TL;DR: It is shown that plants with reduced COP9 signalosome levels had decreased auxin response similar to loss-of-function mutants of the E3 ubiquitin ligase SCFTIR1, and that the COP9 signosome was required for efficient degradation of PSIAA6, a candidate substrate of SC FTIR1.