O
Oliver Hartley
Researcher at University of Geneva
Publications - 104
Citations - 5593
Oliver Hartley is an academic researcher from University of Geneva. The author has contributed to research in topics: Chemokine & Chemokine receptor. The author has an hindex of 30, co-authored 102 publications receiving 5273 citations. Previous affiliations of Oliver Hartley include Hull York Medical School & Swiss Institute of Bioinformatics.
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Journal ArticleDOI
Isolation of high affinity human antibodies directly from large synthetic repertoires.
Andrew D. Griffiths,S C Williams,Oliver Hartley,I M Tomlinson,Peter M. Waterhouse,William L. Crosby,Roland E. Kontermann,Peter T. Jones,N. M. Low,T. J. Allison +9 more
TL;DR: This work created highly diverse repertoires of heavy and light chains entirely in vitro from a bank of human V gene segments and generated a large synthetic repertoire of Fab fragments displayed on filamentous phage to help dissect the contributions of biological mechanisms and structural features governing V gene usage in vivo.
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Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases.
TL;DR: In this paper, the spatial and cellular distribution of chemokine receptors in the brain, distinguishing between constitutively and inducibly expressed receptors, and possible physiological functions, including neuronal migration, cell proliferation and synaptic activity.
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Prevention of Vaginal SHIV Transmission in Rhesus Macaques Through Inhibition of CCR5
Michael M. Lederman,Ronald S. Veazey,Robin E. Offord,Donald E. Mosier,Jason Dufour,Megan Mefford,Michael Piatak,Jeffrey D. Lifson,Janelle R. Salkowitz,Benigno Rodriguez,Andrew Blauvelt,Oliver Hartley +11 more
TL;DR: Topical application of high doses of PSC-RANTES, an amino terminus–modified analog of the chemokine RANTES, provided potent protection against vaginal challenge in rhesus macaques, and have potentially important implications for understanding vaginal transmission of HIV and the design of strategies for its prevention.
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V3: HIV's switch-hitter.
TL;DR: Recent advances in the understanding of V3 as a determinant of viral tropism are reviewed, and how this new knowledge may inform the development of HIV-1 drugs and vaccines are discussed.
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Microbicides and other topical strategies to prevent vaginal transmission of HIV.
TL;DR: The targets for topical agents that have been identified by studies of the biology of HIV infection are discussed and an overview of the progress towards the development of a usable agent is provided.