Wim Brugman

TL;DR: A repressive chromatin type is identified that covers about half of the genome and lacks classic heterochromatin markers and transcriptionally active euchromatin consists of two types that differ in molecular organization and H3K36 methylation and regulate distinct classes of genes.

TL;DR: High-resolution maps of genome-nuclear lamina interactions during subsequent differentiation of mouse embryonic stem cells via lineage-committed neural precursor cells into terminally differentiated astrocytes suggest that lamina-genome interactions are widely involved in the control of gene expression programs during lineage commitment and terminal differentiation.

TL;DR: This approach provides a global overview of kinase fusion events, irrespective of the identity of the fusion partner, and identifies numerous genetic alterations impacting fibroblast growth factor receptor 3 in lung squamous cell carcinoma and a novel ALK fusion partner in lung adenocarcinoma.

TL;DR: The detailed structure of LADs in Drosophila cells is reported, and SU(HW) is identified as a fine-tuner of genome – NL interactions as well as five insulator proteins in LAD organization.

TL;DR: A robotic spotting system, an array of hundreds of oligonucleotide spots is deposited on the surface of a flat, dendrimer-modified stamp that is subsequently used for repeated replication of the entire microarray by microcontact printing, characterized by homogeneous probe density and regular spot morphology.