Wendy Talhout

TL;DR: A high-resolution map of the interaction sites of the entire genome with NL components in human fibroblasts is constructed and demonstrates that the human genome is divided into large, discrete domains that are units of chromosome organization within the nucleus.

TL;DR: A repressive chromatin type is identified that covers about half of the genome and lacks classic heterochromatin markers and transcriptionally active euchromatin consists of two types that differ in molecular organization and H3K36 methylation and regulate distinct classes of genes.

TL;DR: This genome-wide analysis gives clear insight into the nature and dynamic behavior of the genome at the nuclear lamina, and implies that intergenic DNA functions in the global organization of chromatin in the nucleus.

TL;DR: A genome-wide approach to map binding patterns of PcG proteins (Pc, esc and Sce) in Drosophila melanogaster Kc cells found that Pc associates with large genomic regions of up to ∼150 kb in size, hereafter referred to as 'Pc domains'.

TL;DR: Colocalization hotspots constitute a previously uncharacterized type of feature in the genome of Drosophila, and the results provide insights into the general targeting mechanisms of transcription regulators in a higher eukaryote.