J
Jop Kind
Researcher at Utrecht University
Publications - 32
Citations - 4790
Jop Kind is an academic researcher from Utrecht University. The author has contributed to research in topics: Chromatin & Nuclear lamina. The author has an hindex of 22, co-authored 32 publications receiving 4216 citations. Previous affiliations of Jop Kind include Netherlands Cancer Institute & Royal Netherlands Academy of Arts and Sciences.
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Journal ArticleDOI
Systematic Protein Location Mapping Reveals Five Principal Chromatin Types in Drosophila Cells
Guillaume J. Filion,Joke G. van Bemmel,Ulrich Braunschweig,Wendy Talhout,Jop Kind,Lucas D. Ward,Wim Brugman,Ines J de Castro,Ron M. Kerkhoven,Harmen J. Bussemaker,Bas van Steensel +10 more
TL;DR: A repressive chromatin type is identified that covers about half of the genome and lacks classic heterochromatin markers and transcriptionally active euchromatin consists of two types that differ in molecular organization and H3K36 methylation and regulate distinct classes of genes.
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Single-Cell Dynamics of Genome-Nuclear Lamina Interactions
Jop Kind,Ludo Pagie,Havva Ortabozkoyun,Shelagh Boyle,Sandra S. de Vries,Hans Janssen,Mario Amendola,Leisha D. Nolen,Wendy A. Bickmore,Bas van Steensel +9 more
TL;DR: The H3K9 methyltransferase G9a is identified as a regulator of NL contacts and contact of individual LADs with the NL is linked to transcriptional repression and H 3K9 dimethylation in single cells.
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Nuclear pore components are involved in the transcriptional regulation of dosage compensation in Drosophila
Sascha Mendjan,Mikko Taipale,Jop Kind,Herbert Holz,Philipp Gebhardt,Malgorzata Schelder,Michiel Vermeulen,Alessia Buscaino,Kent Duncan,Juerg Mueller,Matthias Wilm,Henk Stunnenberg,Harald Saumweber,Asifa Akhtar +13 more
TL;DR: The purification of enzymatically active MSL complexes from Drosophila embryos, Schneider cells, and human HeLa cells reveals an unexpected physical and functional connection between nuclear pore components and chromatin regulation through MSL proteins, highlighting the role of nucleoporins in gene regulation in higher eukaryotes.
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Constitutive nuclear lamina–genome interactions are highly conserved and associated with A/T-rich sequence
Wouter Meuleman,Daan Peric-Hupkes,Jop Kind,Jean-Bernard Beaudry,Ludo Pagie,Manolis Kellis,Manolis Kellis,Marcel J. T. Reinders,Lodewyk F. A. Wessels,Lodewyk F. A. Wessels,Bas van Steensel +10 more
TL;DR: Results reveal that the spatial organization of mammalian genomes is highly conserved and tightly linked to local nucleotide composition.
Journal ArticleDOI
Genome-wide Maps of Nuclear Lamina Interactions in Single Human Cells
Jop Kind,Jop Kind,Ludo Pagie,Sandra S. de Vries,Leila Nahidiazar,Siddharth S. Dey,Magda Bienko,Ye Zhan,Bryan R. Lajoie,Carolyn A. de Graaf,Mario Amendola,Geoffrey Fudenberg,Maxim Imakaev,Leonid A. Mirny,Kees Jalink,Job Dekker,Alexander van Oudenaarden,Bas van Steensel +17 more
TL;DR: The consistency of NL contacts is inversely linked to gene activity in single cells and correlates positively with the heterochromatic histone modification H3K9me3, which highlights fundamental principles of single-cell chromatin organization.