Wivijin Piga

TL;DR: Both MRE and ultrasound have high sensitivity for detecting small bowel disease presence and both are valid first-line investigations, and viable alternatives to ileocolonoscopy.

TL;DR: WB-MRI staging pathways have similar accuracy to standard pathways, and reduce the staging time and costs, and per-patient agreement for local T and N stage is found.

TL;DR: Fractional intracellular volume demonstrates high repeatability and image quality and enables better differentiation of a Gleason 4 component cancer from benign and/or Gleason 3+3 histology than apparent diffusion coefficient.

TL;DR: WB-MRI staging pathways have similar accuracy to standard pathways and reduce the number of tests needed, staging time, and cost, as well as differences in treatment decisions and staging efficiency.

TL;DR: This work reports on the first-in-human in vivo non-invasive metabolic interrogation of renal cell carcinoma using hyperpolarized carbon-13 (13C) MRI and describes the validation of in vivo lactate metabolic heterogeneity against multi regional ex vivo mass spectrometry.