Institution
Princess Alexandra Hospital NHS Trust
Healthcare•Harlow, United Kingdom•
About: Princess Alexandra Hospital NHS Trust is a healthcare organization based out in Harlow, United Kingdom. It is known for research contribution in the topics: Medicine & Prostate cancer. The organization has 243 authors who have published 177 publications receiving 4040 citations. The organization is also known as: Princess Alexandra Hospital NHS Trust.
Topics: Medicine, Prostate cancer, Population, Cancer, Health care
Papers published on a yearly basis
Papers
More filters
University College London1, London Research Institute2, University of Leicester3, Francis Crick Institute4, University of Manchester5, University of Birmingham6, Glenfield Hospital7, Middlesex University8, Princess Alexandra Hospital NHS Trust9, Cardiff University10, University of Oxford11, Max Delbrück Center for Molecular Medicine12, Katholieke Universiteit Leuven13
TL;DR: Intratumor heterogeneity mediated through chromosome instability was associated with an increased risk of recurrence or death, a finding that supports the potential value of chromosome instability as a prognostic predictor.
Abstract: BackgroundAmong patients with non–small-cell lung cancer (NSCLC), data on intratumor heterogeneity and cancer genome evolution have been limited to small retrospective cohorts. We wanted to prospectively investigate intratumor heterogeneity in relation to clinical outcome and to determine the clonal nature of driver events and evolutionary processes in early-stage NSCLC. MethodsIn this prospective cohort study, we performed multiregion whole-exome sequencing on 100 early-stage NSCLC tumors that had been resected before systemic therapy. We sequenced and analyzed 327 tumor regions to define evolutionary histories, obtain a census of clonal and subclonal events, and assess the relationship between intratumor heterogeneity and recurrence-free survival. ResultsWe observed widespread intratumor heterogeneity for both somatic copy-number alterations and mutations. Driver mutations in EGFR, MET, BRAF, and TP53 were almost always clonal. However, heterogeneous driver alterations that occurred later in evolution w...
1,679 citations
University of Genoa1, Mayo Clinic2, Innsbruck Medical University3, Medical University of Graz4, Medical University of Vienna5, University of Copenhagen6, Sapienza University of Rome7, University of Barcelona8, University of Gothenburg9, Marmara University10, Princess Alexandra Hospital NHS Trust11, Cambridge University Hospitals NHS Foundation Trust12, University of Leeds13, University of Oxford14
TL;DR: According to these provisional classification criteria, patients ≥50 years old presenting with bilateral shoulder pain, not better explained by an alternative pathology, can be classified as having PMR in the presence of morning stiffness>45 minutes, elevated CRP and/or ESR and new hip pain.
Abstract: The objective of this study was to develop EULAR/ACR classification criteria for polymyalgia rheumatica (PMR). Candidate criteria were evaluated in a 6-month prospective cohort study of 125 patients with new onset PMR and 169 non-PMR comparison subjects with conditions mimicking PMR. A scoring algorithm was developed based on morning stiffness >45 minutes (2 points), hip pain/limited range of motion (1 point), absence of RF and/or ACPA (2 points), and absence of peripheral joint pain (1 point). A score ≥4 had 68% sensitivity and 78% specificity for discriminating all comparison subjects from PMR. The specificity was higher (88%) for discriminating shoulder conditions from PMR and lower (65%) for discriminating RA from PMR. Adding ultrasound, a score ≥5 had increased sensitivity to 66% and specificity to 81%. According to these provisional classification criteria, patients ≥50 years old presenting with bilateral shoulder pain, not better explained by an alternative pathology, can be classified as having PMR in the presence of morning stiffness>45 minutes, elevated CRP and/or ESR and new hip pain. These criteria are not meant for diagnostic purposes.
535 citations
Utrecht University1, Case Western Reserve University2, National University of Colombia3, Technical University of Denmark4, Dalle Molle Institute for Artificial Intelligence Research5, Işık University6, French Institute of Health and Medical Research7, PSL Research University8, Curie Institute9, National Taiwan University of Science and Technology10, Konica Minolta11, Panasonic12, University of Central Lancashire13, University of Nice Sophia Antipolis14, University of Surrey15, University of Sheffield16, University of Warwick17, Qatar University18, Princess Alexandra Hospital NHS Trust19
TL;DR: The results from the Assessment of Mitosis Detection Algorithms 2013 (AMIDA13) challenge are described and the top performing method has an error rate that is comparable to the inter-observer agreement among pathologists.
405 citations
TL;DR: This work discovers and validate six previously unknown risk loci for PBC and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine–cytokine pathways, for which relevant therapies exist.
Abstract: Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (Pcombined<5 × 10(-8)) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine-cytokine pathways, for which relevant therapies exist.
245 citations
University of Genoa1, Mayo Clinic2, Innsbruck Medical University3, Medical University of Graz4, University of Copenhagen5, Sapienza University of Rome6, University of Barcelona7, University of Gothenburg8, Marmara University9, Princess Alexandra Hospital NHS Trust10, Cambridge University Hospitals NHS Foundation Trust11, University of Leeds12, University of Oxford13
TL;DR: According to these provisional classification criteria, patients ≥50 years old presenting with bilateral shoulder pain, not better explained by an alternative pathology, can be classified as having PMR in the presence of morning stiffness >45 minutes, elevated C-reactive protein and/or erythrocyte sedimentation rate, and new hip pain.
Abstract: The objective of this study was to develop European League Against Rheumatism/American College of Rheumatology classification criteria for polymyalgia rheumatica (PMR). Candidate criteria were evaluated in a 6-month prospective cohort study of 125 patients with new-onset PMR and 169 non-PMR comparison subjects with conditions mimicking PMR. A scoring algorithm was developed based on morning stiffness >45 minutes (2 points), hip pain/limited range of motion (1 point), absence of rheumatoid factor and/or anti–citrullinated protein antibody (2 points), and absence of peripheral joint pain (1 point). A score ≥4 had 68% sensitivity and 78% specificity for discriminating all comparison subjects from PMR. The specificity was higher (88%) for discriminating shoulder conditions from PMR and lower (65%) for discriminating RA from PMR. Adding ultrasound, a score ≥5 had increased sensitivity to 66% and specificity to 81%. According to these provisional classification criteria, patients ≥50 years old presenting with bilateral shoulder pain, not better explained by an alternative pathology, can be classified as having PMR in the presence of morning stiffness >45 minutes, elevated C-reactive protein and/or erythrocyte sedimentation rate, and new hip pain. These criteria are not meant for diagnostic purposes.
234 citations
Authors
Showing all 249 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Bryan Burmeister | 39 | 158 | 7908 |
| Manit Arya | 35 | 170 | 3945 |
| Hitendra R.H. Patel | 18 | 59 | 1428 |
| Ankur Thapar | 18 | 68 | 905 |
| C Michael Roberts | 17 | 50 | 1376 |
| Caris E Grimes | 15 | 36 | 2648 |
| Roberto Verdolini | 11 | 31 | 387 |
| Cinzia Papadia | 10 | 23 | 345 |
| Manit Arya | 9 | 18 | 340 |
| Sidhartha Sinha | 9 | 12 | 352 |
| Peter Russell | 9 | 17 | 2940 |
| Raj Nigam | 7 | 24 | 293 |
| Eoin Macdonald-Nethercott | 6 | 8 | 86 |
| Konstantinos Stergios | 6 | 14 | 106 |
| Jaspal Virdi | 6 | 24 | 1429 |