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Wolfgang Ruf
Researcher at University of Ulm
Publications - 36
Citations - 2500
Wolfgang Ruf is an academic researcher from University of Ulm. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 14, co-authored 23 publications receiving 1992 citations. Previous affiliations of Wolfgang Ruf include Harvard University & University of Graz.
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Journal ArticleDOI
Exosomal cell-to-cell transmission of alpha synuclein oligomers
Karin M Danzer,Karin M Danzer,Lisa R. Kranich,Wolfgang Ruf,Ozge Cagsal-Getkin,Ashley R. Winslow,Liya Zhu,Charles R. Vanderburg,Pamela J. McLean,Pamela J. McLean +9 more
TL;DR: The data suggest that αsyn may be secreted via different secretory pathways, and hypothesize that exosome-mediated release of αsyn oligomers is a mechanism whereby cells clear toxic α synuclein oligomers when autophagic mechanisms fail to be sufficient.
Journal ArticleDOI
Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia
Axel Freischmidt,Thomas Wieland,Benjamin Richter,Wolfgang Ruf,Veronique Schaeffer,Kathrin Muller,Nicolai Marroquin,Frida Nordin,Annemarie Hübers,Patrick Weydt,Susana Pinto,Rayomond Press,Stéphanie Millecamps,Nicolas Molko,Emilien Bernard,Claude Desnuelle,Marie-Hélène Soriani,Johannes Dorst,Elisabeth Graf,Ulrika Nordström,Marisa S. Feiler,Stefan Putz,Tobias M. Boeckers,Thomas F. Meyer,Andrea Sylvia Winkler,Juliane Winkelman,Mamede de Carvalho,Dietmar Rudolf Thal,Markus Otto,Thomas Brännström,Alexander E Volk,Petri Kursula,Karin M Danzer,Peter Lichtner,Ivan Dikic,Thomas Meitinger,Albert C. Ludolph,Tim M. Strom,Peter M Andersen,Jochen H. Weishaupt +39 more
TL;DR: It is concluded that haploinsufficiency of TBK1 causes ALS and fronto-temporal dementia.
Journal ArticleDOI
Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity
Karin M Danzer,Wolfgang Ruf,Preeti Putcha,Daniel Joyner,Tadafumi Hashimoto,Charles G. Glabe,Bradley T. Hyman,Pamela J. McLean +7 more
TL;DR: In a cellular model, the presence of αsyn oligomers in the extracellular space, their uptake by neurons, retrograde axonal transport to cell soma, and detrimental effects on neighboring cells are demonstrated and their modulation by Hsp70 represents a potential new target for therapeutic interventions.
Journal ArticleDOI
Inflammatory dysregulation of blood monocytes in Parkinson’s disease patients
Veselin Grozdanov,Corinna Bliederhaeuser,Wolfgang Ruf,Valerie Roth,Kathrin Fundel-Clemens,Lisa Zondler,David A. Brenner,Ana Martin-Villalba,Bastian Hengerer,Jan Kassubek,Albert C. Ludolph,Jochen H. Weishaupt,Karin M Danzer +12 more
TL;DR: It is found that the classical monocytes are enriched in the blood of PD patients along with an increase in the monocyte-recruiting chemoattractant protein CCL2 and the CD95/CD95L is identified as a key regulator for the PD-associated alteration of circulating monocytes.
Journal ArticleDOI
Hot-spot KIF5A mutations cause familial ALS
David A. Brenner,Rüstem Yilmaz,Kathrin Muller,Torsten Grehl,Susanne Petri,Thomas F. Meyer,Julian Grosskreutz,Patrick Weydt,Patrick Weydt,Wolfgang Ruf,Christoph Neuwirth,Markus Weber,Susana Pinto,Kristl G. Claeys,Berthold Schrank,Berit Jordan,Antje Knehr,Kornelia Günther,Annemarie Hübers,Daniel Zeller,Christian Kubisch,Christian Kubisch,Sibylle Jablonka,Michael Sendtner,Thomas Klopstock,Thomas Klopstock,Mamede de Carvalho,Anne D. Sperfeld,Guntram Borck,Alexander E Volk,Alexander E Volk,Johannes Dorst,Joachim Weis,Markus Otto,Joachim Schuster,Kelly Del Tredici,Heiko Braak,Karin M Danzer,Axel Freischmidt,Thomas Meitinger,Thomas Meitinger,Tim M. Strom,Tim M. Strom,Albert C. Ludolph,Peter M. Andersen,Peter M. Andersen,Jochen H. Weishaupt +46 more
TL;DR: Experiments using patient-derived cell lines suggest haploinsufficiency as the molecular genetic mechanism for classical ALS, which underlines the relevance of intracellular transport processes for ALS, and is important for clinico-genetic diagnosis and counselling.