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Christian Kubisch

Researcher at University of Hamburg

Publications -  210
Citations -  16034

Christian Kubisch is an academic researcher from University of Hamburg. The author has contributed to research in topics: Missense mutation & Gene. The author has an hindex of 55, co-authored 197 publications receiving 14141 citations. Previous affiliations of Christian Kubisch include University of Melbourne & University of Ulm.

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Analysis of shared heritability in common disorders of the brain

Verneri Anttila, +720 more
- 22 Jun 2018 - 
TL;DR: It is demonstrated that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine, and it is shown that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures.
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Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase.

Alfredo Ramirez, +16 more
- 10 Sep 2006 - 
TL;DR: Loss-of-function mutations in a previously uncharacterized, predominantly neuronal P-type ATPase gene, ATP13A2, underlying an autosomal recessive form of early-onset parkinsonism with pyramidal degeneration and dementia are described.
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A Potassium Channel Mutation in Neonatal Human Epilepsy

Christian Biervert, +18 more
- 16 Jan 1998 - 
TL;DR: Impairment of potassium-dependent repolarization is likely to cause this age-specific epileptic syndrome.
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KCNQ4, a Novel Potassium Channel Expressed in Sensory Outer Hair Cells, Is Mutated in Dominant Deafness

Christian Kubisch, +7 more
- 05 Feb 1999 - 
TL;DR: A novel member of the KCNQ branch of the K+ channel gene family, cloned, which maps to the DFNA2 locus for a form of nonsyndromic dominant deafness and abolishes the potassium currents of wild-typeKCNQ4 on which it exerts a strong dominant-negative effect.
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Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene

Alfons Meindl, +24 more
- 01 May 2010 - 
TL;DR: In index cases from 1,100 German families with gynecological malignancies, the first unambiguous evidence of highly penetrant mutations associated with human cancer in a RAD51 paralog is provided and support the 'common disease, rare allele' hypothesis.