BackgroundPembrolizumab is a humanized monoclonal antibody against programmed death 1 (PD-1) that has antitumor activity in advanced non–small-cell lung cancer (NSCLC), with increased activity in tumors that express programmed death ligand 1 (PD-L1). MethodsIn this open-label, phase 3 trial, we randomly assigned 305 patients who had previously untreated advanced NSCLC with PD-L1 expression on at least 50% of tumor cells and no sensitizing mutation of the epidermal growth factor receptor gene or translocation of the anaplastic lymphoma kinase gene to receive either pembrolizumab (at a fixed dose of 200 mg every 3 weeks) or the investigator’s choice of platinum-based chemotherapy. Crossover from the chemotherapy group to the pembrolizumab group was permitted in the event of disease progression. The primary end point, progression-free survival, was assessed by means of blinded, independent, central radiologic review. Secondary end points were overall survival, objective response rate, and safety. ResultsMedi...

https://www.nejm.org/doi/suppl/10.1056/NEJMoa1606774/suppl_file/nejmoa1606774_protocol.pdf

Pembrolizumab versus Chemotherapy for PD-L1–Positive Non–Small-Cell Lung Cancer

The 11th edition of Harrison's Principles of Internal Medicine welcomes Anthony Fauci to its editorial staff, in addition to more than 85 new contributors. While the organization of the book is similar to previous editions, major emphasis has been placed on disorders that affect multiple organ systems. Important advances in genetics, immunology, and oncology are emphasized. Many chapters of the book have been rewritten and describe major advances in internal medicine. Subjects that received only a paragraph or two of attention in previous editions are now covered in entire chapters. Among the chapters that have been extensively revised are the chapters on infections in the compromised host, on skin rashes in infections, on many of the viral infections, including cytomegalovirus and Epstein-Barr virus, on sexually transmitted diseases, on diabetes mellitus, on disorders of bone and mineral metabolism, and on lymphadenopathy and splenomegaly. The major revisions in these chapters and many

Harrison's Principles of Internal Medicine

https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(10)61121-X.pdf

Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial

In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes.

For example, a key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process versus those that measure flux through the autophagy pathway (i.e., the complete process including the amount and rate of cargo sequestered and degraded). In particular, a block in macroautophagy that results in autophagosome accumulation must be differentiated from stimuli that increase autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. It is worth emphasizing here that lysosomal digestion is a stage of autophagy and evaluating its competence is a crucial part of the evaluation of autophagic flux, or complete autophagy.

Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. Along these lines, because of the potential for pleiotropic effects due to blocking autophagy through genetic manipulation, it is imperative to target by gene knockout or RNA interference more than one autophagy-related protein. In addition, some individual Atg proteins, or groups of proteins, are involved in other cellular pathways implying that not all Atg proteins can be used as a specific marker for an autophagic process. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular assays, we hope to encourage technical innovation in the field.

/pdf/guidelines-for-the-use-and-interpretation-of-assays-for-ijf2t30pbq.pdf

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

The Internet has led to the creation of a digital society, where (almost) everything is connected and is accessible from anywhere. However, despite their widespread adoption, traditional IP networks are complex and very hard to manage. It is both difficult to configure the network according to predefined policies, and to reconfigure it to respond to faults, load, and changes. To make matters even more difficult, current networks are also vertically integrated: the control and data planes are bundled together. Software-defined networking (SDN) is an emerging paradigm that promises to change this state of affairs, by breaking vertical integration, separating the network's control logic from the underlying routers and switches, promoting (logical) centralization of network control, and introducing the ability to program the network. The separation of concerns, introduced between the definition of network policies, their implementation in switching hardware, and the forwarding of traffic, is key to the desired flexibility: by breaking the network control problem into tractable pieces, SDN makes it easier to create and introduce new abstractions in networking, simplifying network management and facilitating network evolution. In this paper, we present a comprehensive survey on SDN. We start by introducing the motivation for SDN, explain its main concepts and how it differs from traditional networking, its roots, and the standardization activities regarding this novel paradigm. Next, we present the key building blocks of an SDN infrastructure using a bottom-up, layered approach. We provide an in-depth analysis of the hardware infrastructure, southbound and northbound application programming interfaces (APIs), network virtualization layers, network operating systems (SDN controllers), network programming languages, and network applications. We also look at cross-layer problems such as debugging and troubleshooting. In an effort to anticipate the future evolution of this new paradigm, we discuss the main ongoing research efforts and challenges of SDN. In particular, we address the design of switches and control platforms—with a focus on aspects such as resiliency, scalability, performance, security, and dependability—as well as new opportunities for carrier transport networks and cloud providers. Last but not least, we analyze the position of SDN as a key enabler of a software-defined environment.

https://publications.uni.lu/bitstream/10993/20596/1/survey_on_SDN.pdf

Software-Defined Networking: A Comprehensive Survey

This study is to verify the effects of various physical therapies to improve postural control which is necessary for safe and independent daily life in people with cerebral palsy. For this, meta-analysis was completed on related studies published in Korea. A systematic search was performed using 5 electric database to collect articles. Group experiment designs were included. Studies were classified into 4 categories: neurodevelopmental treatment, task oriented approach, therapeutic exercise, and neuromuscular stimulation. Outcomes included dynamic balance, static balance, and motor function. A total of 30 trials was included among initial 380 studies. Neurodevelopmental treatment, task oriented approach, therapeutic exercise, and neuromuscular stimulation significantly improved postural control, but there were no difference between therapies(p>.05). These treatments not only had a positive effect on the improvement of dynamic and static balance, but also had a positive effect on muscle function. The effect size of various physical therapies for postural control in people with cerebral palsy was medium and significant. Based on this meta-analysis, sufficient intervention time can be helpful for more effective postural control intervention. 

The Effects of Intervention of Postural Control in People with Cerebral Palsy : A Meta-analysis

The spoke type permanent magnet synchronous motor (PMSM), which is a general ferrite magnetic flux concentrated motor, has a low portion of reluctance torque at the total torque magnitude. Therefore, as a way to increase the reluctance torque, there is a double-layer spoke type PMSM that can maximize the difference in inductance between the d-axis and the q-axis. However, in the double-layer spoke type PMSM, cogging torque, torque ripple, and total harmonic distortion (THD) of Load Line EMF increase as reluctance torque is maximized, which is the main cause of vibration and noise. As a representative method, it can be solved by applying skew to the rotor, but the conventional method of applying skew is not a good method in terms of productivity because it is difficult to manufacture because it divides the stages of the permanent magnet. Therefore, in this paper, the skew is not applied to the rotor and the asymmetrical design of the shoe is carried out in the stator. Then, we propose a new stator shape that can apply a Skew-like effect by cross-stacking stators using the asymmetric designed stator. Based on the method, the reduction of cogging torque and THD was verified by Finite Element Analysis (FEA).

A Study on Stator Shape to Reduce Cogging Torque and Torque Ripple of Double-Layer Spoke Type PMSM

Postoperative NSAIDs use and the risk of anastomotic leakage after restorative resection for colorectal cancer.

Axial flux motors have a large output density with a large outer diameter of the motor and a short axial length. Since it is advantageous in short axial length, the axial thickness of motor components becomes a very important parameter when designing axial flux motors. Among the components, the back yoke exists to serve as a path for magnetic flux and must have a certain thickness to prevent magnetic saturation. However, as the thickness of the back yoke increases within the axial size limit of the motor, the output of the motor may decrease. In this paper, same-direction skew that increases the cross-sectional area of the magnetic flux path without increasing the thickness of the back yoke is presented. Same-direction skew is a way to increase the cross-sectional area of the back yoke by skewing the rotor and stator in the same direction. The back yoke thickness that can be reduced by same-direction skew was calculated. Performance with same-direction skew designed using the equations was analyzed and compared, and the effectiveness of each type of rotor was verified. The validity of the proposed model was examined using the finite element analysis method.

/pdf/a-study-on-the-improvement-of-power-density-of-axial-flux-2d8t2r1k.pdf

Won Ho Kim

Papers

The Effects of Intervention of Postural Control in People with Cerebral Palsy : A Meta-analysis

A Study on Stator Shape to Reduce Cogging Torque and Torque Ripple of Double-Layer Spoke Type PMSM

Postoperative NSAIDs use and the risk of anastomotic leakage after restorative resection for colorectal cancer.

A Study on the Improvement of Power Density of Axial Flux Motors for Collaborative Robot Joints through Same-Direction Skew

Dispersion of functional tetraphenylporphyrin-ligated metal into ultra-thin flexible acrylate films. 2. Oxygen-uptake properties.