W
Wouter Lokhorst
Researcher at Wageningen University and Research Centre
Publications - 3
Citations - 475
Wouter Lokhorst is an academic researcher from Wageningen University and Research Centre. The author has contributed to research in topics: Scale (ratio) & Gene cluster. The author has an hindex of 2, co-authored 3 publications receiving 250 citations.
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A computational framework to explore large-scale biosynthetic diversity
Jorge C. Navarro-Muñoz,Nelly Selem-Mojica,Michael W. Mullowney,Satria A. Kautsar,James H. Tryon,Elizabeth I. Parkinson,Elizabeth I. Parkinson,Emmanuel L. C. de los Santos,Marley Yeong,Pablo Cruz-Morales,Sahar Abubucker,Arne Roeters,Wouter Lokhorst,Antonio Fernandez-Guerra,Antonio Fernandez-Guerra,Antonio Fernandez-Guerra,Luciana Teresa Dias Cappelini,Anthony W. Goering,Regan J. Thomson,William W. Metcalf,Neil L. Kelleher,Francisco Barona-Gómez,Marnix H. Medema +22 more
TL;DR: Two bioinformatic tools enable sequence similarity network and phylogenetic analysis of gene clusters and their families across hundreds of strains and in large datasets, leading to the discovery of new natural products.
Posted ContentDOI
A computational framework for systematic exploration of biosynthetic diversity from large-scale genomic data
Jorge C. Navarro-Muñoz,Nelly Selem-Mojica,Michael W. Mullowney,Satria A. Kautsar,James H. Tryon,Elizabeth I. Parkinson,Emmanuel L. C. de los Santos,Marley Yeong,Pablo Cruz-Morales,Sahar Abubucker,Arne Roeters,Wouter Lokhorst,Antonio Fernandez-Guerra,Luciana Teresa Dias Cappelini,Regan J. Thomson,William W. Metcalf,Neil L. Kelleher,Francisco Barona-Gómez,Marnix H. Medema +18 more
TL;DR: The discovery potential of the BiG-SCAPE platform is demonstrated by using CORASON to comprehensively map the phylogenetic diversity of the large detoxin/rimosamide gene cluster clan, prioritizing three new detoxin families for subsequent characterization of six new analogs using isotopic labeling and analysis of tandem mass spectrometric data.
Genomic data for "A computational framework to explore large-scale biosynthetic diversity"
Jorge C. Navarro-Muñoz,Nelly Selem-Mojica,Michael W. Mullowney,Satria A. Kautsar,James H. Tryon,Elizabeth I. Parkinson,Emmanuel L. C. de los Santos,Marley Yeong,Pablo Cruz-Morales,Sahar Abubucker,Arne Roeters,Wouter Lokhorst,Antonio Fernandez-Guerra,Luciana Teresa Dias Cappelini,Anthony W. Goering,Regan J. Thomson,William W. Metcalf,Neil L. Kelleher,Francisco Barona-Gómez,Marnix H. Medema +19 more