R
Regan J. Thomson
Researcher at Northwestern University
Publications - 116
Citations - 3572
Regan J. Thomson is an academic researcher from Northwestern University. The author has contributed to research in topics: Total synthesis & Enantioselective synthesis. The author has an hindex of 32, co-authored 116 publications receiving 2803 citations. Previous affiliations of Regan J. Thomson include University of Wisconsin-Madison & Australian National University.
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A computational framework to explore large-scale biosynthetic diversity
Jorge C. Navarro-Muñoz,Nelly Selem-Mojica,Michael W. Mullowney,Satria A. Kautsar,James H. Tryon,Elizabeth I. Parkinson,Elizabeth I. Parkinson,Emmanuel L. C. de los Santos,Marley Yeong,Pablo Cruz-Morales,Sahar Abubucker,Arne Roeters,Wouter Lokhorst,Antonio Fernandez-Guerra,Antonio Fernandez-Guerra,Antonio Fernandez-Guerra,Luciana Teresa Dias Cappelini,Anthony W. Goering,Regan J. Thomson,William W. Metcalf,Neil L. Kelleher,Francisco Barona-Gómez,Marnix H. Medema +22 more
TL;DR: Two bioinformatic tools enable sequence similarity network and phylogenetic analysis of gene clusters and their families across hundreds of strains and in large datasets, leading to the discovery of new natural products.
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Enantioselective synthesis of biphenols from 1,4-diketones by traceless central-to-axial chirality exchange.
TL;DR: A stereochemical model for this chirality exchange process is put forth on the basis of X-ray crystallographic data, and key to the success of this method is the highly selective transfer of central to axial chorality during a double aromatization event triggered by BF(3)·OEt(2).
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Oxidative Coupling of Enolates, Enol Silanes, and Enamines: Methods and Natural Product Synthesis
TL;DR: There have been a number of reports from several research groups demonstrating advances in several neglected areas of oxidative coupling, and this microreview summarizes these new advances and provides an overview of recent natural product syntheses that showcase the power of these transformations.
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Structure, Chemical Synthesis, and Biosynthesis of Prodiginine Natural Products
TL;DR: This review provides a comprehensive overview of research undertaken toward the isolation and structural elucidation of the prodiginine family of natural products.
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Metabologenomics: Correlation of Microbial Gene Clusters with Metabolites Drives Discovery of a Nonribosomal Peptide with an Unusual Amino Acid Monomer
Anthony W. Goering,Ryan A. McClure,James R. Doroghazi,Jessica C. Albright,Nicole A. Haverland,Yongbo Zhang,Kou San Ju,Regan J. Thomson,William W. Metcalf,Neil L. Kelleher +9 more
TL;DR: The discovery of tambromycin via large-scale correlation of gene clusters with metabolites illuminates a path for structure-based discovery of natural products at a sharply increased rate.