James H. Tryon

TL;DR: Two bioinformatic tools enable sequence similarity network and phylogenetic analysis of gene clusters and their families across hundreds of strains and in large datasets, leading to the discovery of new natural products.

TL;DR: The discovery potential of the BiG-SCAPE platform is demonstrated by using CORASON to comprehensively map the phylogenetic diversity of the large detoxin/rimosamide gene cluster clan, prioritizing three new detoxin families for subsequent characterization of six new analogs using isotopic labeling and analysis of tandem mass spectrometric data.

TL;DR: The discovery of the tyrobetaines shows the great potential of metabologenomics combined with molecular networking and computational structure prediction for identifying interesting biosynthetic reactions and novel NPs.

TL;DR: The metabolomics-driven genome mining of a new cyclic-guanidino incorporating non-ribosomal peptide synthetase (NRPS) gene cluster and full structure elucidation of its associated hexapeptide product, faulknamycin, revealed that this natural product contained the previously unknown (R,S)-stereoisomer of capreomycidine, d-capreomyCidine.

TL;DR: The first total synthesis of the furanosesquiterpenoids hibiscone B and acyl hibISCone B is reported in this paper. But the synthesis of these two compounds is still in its infancy.