D
Dhinakaran Sambandan
Researcher at Albert Einstein College of Medicine
Publications - 4
Citations - 760
Dhinakaran Sambandan is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Mycobacterium tuberculosis & Tuberculosis. The author has an hindex of 3, co-authored 4 publications receiving 672 citations. Previous affiliations of Dhinakaran Sambandan include Yeshiva University.
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Journal ArticleDOI
Growth of Mycobacterium tuberculosis biofilms containing free mycolic acids and harbouring drug-tolerant bacteria.
Anil K. Ojha,Anthony D. Baughn,Dhinakaran Sambandan,Tsungda Hsu,Xavier Trivelli,Yann Guérardel,Anuradha Alahari,Laurent Kremer,William R. Jacobs,Graham F. Hatfull +9 more
TL;DR: It is shown that M. tuberculosis forms biofilms with specific environmental and genetic requirements distinct from those for planktonic growth, which contain an extracellular matrix rich in free mycolic acids, and harbour an important drug‐tolerant population that persist despite exposure to high levels of antibiotics.
Journal ArticleDOI
Identification of a small molecule with activity against drug-resistant and persistent tuberculosis
Feng Wang,Dhinakaran Sambandan,Rajkumar Halder,Jianing Wang,Sarah M. Batt,Brian Weinrick,Insha Ahmad,Peng-Yu Yang,Yong Zhang,John Kim,Morad Hassani,Stanislav Huszár,Claudia Trefzer,Zhenkun Ma,Takushi Kaneko,Khisi E. Mdluli,Scott G. Franzblau,Arnab Chatterjee,Kai Johnsson,Katarína Mikušová,Gurdyal S. Besra,Klaus Fütterer,Scott H. Robbins,S. Whitney Barnes,John R. Walker,William R. Jacobs,Peter G. Schultz +26 more
TL;DR: In vitro and in vivo results indicate that this compound functions by a unique mechanism and suggest that TCA1 may lead to the development of a class of antituberculosis agents.
Journal ArticleDOI
Keto-Mycolic Acid-Dependent Pellicle Formation Confers Tolerance to Drug-Sensitive Mycobacterium tuberculosis
Dhinakaran Sambandan,Dee N. Dao,Brian Weinrick,Catherine Vilchèze,Sudagar S. Gurcha,Anil K. Ojha,Laurent Kremer,Laurent Kremer,Gurdyal S. Besra,Graham F. Hatfull,William R. Jacobs +10 more
TL;DR: It is demonstrated that keto-mycolic acids (keto-MA) are essential for pellicle growth, and mutants lacking in or depleted of this MA species are unable to form aPellicle, a biofilm-like structure for Mycobacterium tuberculosis.
Journal ArticleDOI
Identification of a small molecule with activity against drug-resistant and persistent tuberculosis (vol 110, pg E2510, 2013)
Feng Wang,Dhinakaran Sambandan,Rajkumar Halder,Jianing Wang,Sarah M. Batt,Brian Weinrick,Insha Ahmad,Peng-Yu Yang,Yong Zhang,John Kim,Morad Hassani,Stanislav Huszár,Claudia Trefzer,Zhenkun Ma,Takushi Kaneko,Khisi E. Mdluli,Scott G. Franzblau,Arnab Chatterjee,Kai Johnsson,Katarína Mikušová,Gurdyal S. Besra,Klaus Fuetterer,Scott H. Robbins,S. Whitney Barnes,John R. Walker,William R. Jacobs,Peter G. Schultz +26 more
TL;DR: This research presents a novel probabilistic approach to estimating the response of the immune system to laser-spot assisted, 3D image analysis of EMTs.