X
Xi Chen
Researcher at University of California, Davis
Publications - 629
Citations - 28889
Xi Chen is an academic researcher from University of California, Davis. The author has contributed to research in topics: Sialic acid & Medicine. The author has an hindex of 71, co-authored 548 publications receiving 22541 citations. Previous affiliations of Xi Chen include University of California, Riverside & Cleveland Clinic.
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Journal ArticleDOI
Highly efficient chemoenzymatic synthesis of β1–3-linked galactosides
TL;DR: A novel D-galactosyl-β1-3-N-acetyl-D-hexosamine phosphorylase cloned from Bifidobacterium infantis was used with a recombinant E. coli K-12 galactokinase for efficient one-pot two-enzyme synthesis of T-antigens, galacto-n-biose, lacto- N-biOSE, and their derivatives.
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Synthetic disialyl hexasaccharides protect neonatal rats from necrotizing enterocolitis
Hai Yu,Kam Lau,Kam Lau,Vireak Thon,Vireak Thon,Chloe A. Autran,Evelyn Jantscher-Krenn,Mengyang Xue,Mengyang Xue,Yanhong Li,Go Sugiarto,Jingyao Qu,Jingyao Qu,Shengmao Mu,Li Ding,Li Ding,Lars Bode,Xi Chen +17 more
TL;DR: Two novel synthetic α2-6-linked disialyl hexasaccharides, disialyllacto-N-neotetraose and DS'LNT, were readily obtained by highly efficient one-pot multienzyme (OPME) reactions and are good therapeutic candidates for preclinical experiments and clinical application in treating NEC in preterm infants.
Journal ArticleDOI
Tailored Design and Synthesis of Heparan Sulfate Oligosaccharide Analogues Using Sequential One‐Pot Multienzyme Systems
Yi Chen,Yanhong Li,Hai Yu,Go Sugiarto,Vireak Thon,Vireak Thon,Joel Hwang,Li Ding,Li Ding,Liana Hie,Liana Hie,Xi Chen +11 more
TL;DR: Heparan sulfate (HS) and heparin are linear sulfated heteropolysaccharides consisting of alternating α1–4-linked D-glucosamine (GlcN) and 1– 4-linked uronic acid (α-linkage for L-iduronic acid, IdoA, and β- linkage for D- GlcA).
Journal ArticleDOI
HDAC3 is essential for DNA replication in hematopoietic progenitor cells
Alyssa R. Summers,Alyssa R. Summers,Melissa A. Fischer,Kristy R. Stengel,Yue Zhao,Jonathan F. Kaiser,Christina E. Wells,Aubrey Hunt,Srividya Bhaskara,Srividya Bhaskara,Jessica W. Luzwick,Shilpa Sampathi,Xi Chen,Mary Ann Thompson,David Cortez,Scott W. Hiebert +15 more
TL;DR: DNA fiber-labeling experiments indicated that Hdac3 was required for efficient DNA replication in hematopoietic stem and progenitor cells, and for lymphopoiesis.