Xi Chen

TL;DR: It is determined that miR-31 is overexpressed in human lung adenocarcinoma and this overexpression independently correlates with decreased patient survival and is distinguished as a driver of lung tumorigenesis that promotes mutant KRAS-mediated oncogenesis and reveals that mi R-31 directly targets and reduces expression of negative regulators of RAS/MAPK signaling.

TL;DR: A novel and tissue-specific role of claudin-3, a tight junction integral protein, in inhibiting colon cancer progression by serving as the common rheostat of Stat-3 and Wnt-signaling activation is discovered.

TL;DR: Tumor size, open adrenalectomy, and type of α blockade were associated with intraoperative HDI during pheochromocytoma resection and Selective blockade was associated with significantly more episodes of intraoperative hypertension but no perioperative adverse outcomes.

TL;DR: A clone for a rat acidic Ca2+-independent phospholipase A2(aiPLA2) was isolated from a cDNA library prepared from rat granular pneumocytes with a probe based on the human aiPLA2 sequence and results show marked enrichment of a iPLA2 in the lung compared with the other organs and suggest translational control of ai PLA2 expression.

TL;DR: The neuroinflammatory phenotype associated with PGRN deficiency in the CNS is not a direct consequence of the loss of TNF antagonism, but may be a secondary response by glia to disrupted interactions between P GRN and Sortilin and/or other binding partners yet to be identified.