X
Xi Chen
Researcher at University of California, Davis
Publications - 629
Citations - 28889
Xi Chen is an academic researcher from University of California, Davis. The author has contributed to research in topics: Sialic acid & Medicine. The author has an hindex of 71, co-authored 548 publications receiving 22541 citations. Previous affiliations of Xi Chen include University of California, Riverside & Cleveland Clinic.
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Journal ArticleDOI
Synthesis of α-Gal epitope derivatives with a galactosyltransferase–epimerase fusion enzyme
TL;DR: Nine monosaccharides and ten disacchariding were evaluated as substrates for a fusion protein, which contains both alpha-(1-->3)-galactosyltransferase and uridine-5'-diphosphogalactose 4-epimerase.
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A combined NMR, MD and DFT conformational analysis of 9-O-acetyl sialic acid-containing GM3 ganglioside glycan and its 9-N-acetyl mimic.
Wanqing Li,Marcos D. Battistel,Hannah Reeves,Lisa Oh,Hai Yu,Xi Chen,Lee-Ping Wang,Darón I. Freedberg +7 more
TL;DR: Results show that structural modification (O- or N-acetylation) on the C-9 of Neu5Ac in GM3 glycan does not cause significant conformational changes on either its glycosidic dihedral angles or its secondary structure.
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Regioselective One-Pot Multienzyme (OPME) Chemoenzymatic Strategies for Systematic Synthesis of Sialyl Core 2 Glycans.
TL;DR: This work provides a general regioselective strategy to access diverse Core 2 O-GalNAc glycans which can be extended for the synthesis of other complex branched glycans.
Journal Article
Evidence for a role of GPRC6A in prostate cancer metastasis based on case-control and in vitro analyses.
Liu Ming,Zhao Yy,Yang F,Wang Jy,Shi Xh,Zhu Xq,Xu Y,Wei D,Sun L,Zhang Yg,Kehu Yang,Qu Yc,Xinghuan Wang,Liang Sy,Xi Chen,Zhao Cx,Zhu L,Tang L,Zheng Cg,Yang Z +19 more
TL;DR: Findings suggest that GPRC6A is associated with aggressive PCa and may serve as a potential therapeutic target for metastatic PCa, and RUNX2, EMT and ERK signaling were shown to be up-regulated in GPRc6A overexpression cells.
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Effect of RhoC on the epithelial-mesenchymal transition process induced by TGF-β1 in lung adenocarcinoma cells.
TL;DR: It is demonstrated that RhoC was an essential mediator of the EMT process in lung adenocarcinoma cell line A549 which was evaluated by observing the morphological characteristics of the cells and by assessing the expression levels of two EMT marker proteins: E-cadherin and vimentin.