X
Xianjie Jiang
Researcher at Central South University
Publications - 17
Citations - 1088
Xianjie Jiang is an academic researcher from Central South University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 3, co-authored 8 publications receiving 381 citations. Previous affiliations of Xianjie Jiang include Chinese Ministry of Education.
Papers
More filters
Journal ArticleDOI
Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape.
Xianjie Jiang,Xianjie Jiang,Jie Wang,Xiangying Deng,Fang Xiong,Junshang Ge,Junshang Ge,Bo Xiang,Bo Xiang,Xu Wu,Xu Wu,Jian Ma,Jian Ma,Ming Zhou,Ming Zhou,Xiaoling Li,Xiaoling Li,Yong Li,Yong Li,Guiyuan Li,Guiyuan Li,Wei Xiong,Wei Xiong,Can Guo,Can Guo,Zhaoyang Zeng,Zhaoyang Zeng +26 more
TL;DR: Overall, the evidence accumulated to date suggests that induction of PD-L1 by inflammatory factors in the tumor microenvironment may be one of the most important factors affecting the therapeutic efficiency of PD -L1/PD-1 blocking.
Journal ArticleDOI
The role of microenvironment in tumor angiogenesis
Xianjie Jiang,Xianjie Jiang,Jie Wang,Xiangying Deng,Fang Xiong,Shanshan Zhang,Zhaojian Gong,Xiayu Li,Ke Cao,Hao Deng,Yi He,Qianjin Liao,Bo Xiang,Bo Xiang,Ming Zhou,Ming Zhou,Can Guo,Zhaoyang Zeng,Zhaoyang Zeng,Guiyuan Li,Guiyuan Li,Xiaoling Li,Xiaoling Li,Wei Xiong,Wei Xiong +24 more
TL;DR: The regulatory role of the microenvironment in tumor angiogenesis is discussed and high expression of angiogenic factors and inflammatory cytokines in the tumor microenvironment, as well as hypoxia, are presumed to be the reasons for poor therapeutic efficacy of current anti-angiogenic drugs.
Journal ArticleDOI
Epstein-Barr Virus-Encoded Circular RNA CircBART2.2 Promotes Immune Escape of Nasopharyngeal Carcinoma by Regulating PD-L1.
Junshang Ge,Jie Wang,Fang Xiong,Xianjie Jiang,Kunjie Zhu,Yian Wang,Yongzhen Mo,Zhaojian Gong,Shanshan Zhang,Yi He,Xiayu Li,Lei Shi,Can Guo,Fuyan Wang,Ming Zhou,Bo Xiang,Yong Li,Guiyuan Li,Wei Xiong,Zhaoyang Zeng,Zhaoyang Zeng +20 more
TL;DR: In this paper, EBV-encoded circBART2.2 was found to be highly expressed in nasopharyngeal carcinoma (NPC) where it upregulated PD-L1 expression and inhibited T cell function in vitro and in vivo.
Journal ArticleDOI
Circular RNA circRNF13 inhibits proliferation and metastasis of nasopharyngeal carcinoma via SUMO2.
Yongzhen Mo,Yongzhen Mo,Yumin Wang,Yumin Wang,Shuai Zhang,Fang Xiong,Qijia Yan,Xianjie Jiang,Xianjie Jiang,Xiangying Deng,Xiangying Deng,Yian Wang,Yian Wang,Chunmei Fan,Chunmei Fan,Le Tang,Le Tang,Shanshan Zhang,Zhaojian Gong,Fuyan Wang,Qianjin Liao,Can Guo,Yong Li,Xiaoling Li,Xiaoling Li,Guiyuan Li,Guiyuan Li,Zhaoyang Zeng,Zhaoyang Zeng,Wei Xiong,Wei Xiong +30 more
TL;DR: In this article, a new circRNA, circRNF13, was detected in the context of nasopharyngeal carcinoma (NPC) using next-generation sequencing of mRNA.
Journal ArticleDOI
EBV miRNAs BART11 and BART17-3p promote immune escape through the enhancer-mediated transcription of PD-L1
Jie Wang,Junshang Ge,Yian Wang,Fang Xiong,Jiayue Guo,Xianjie Jiang,Lishen Zhang,Xiangying Deng,Zhaojian Gong,Shanshan Zhang,Qijia Yan,Yi He,Xiayu Li,Lei Shi,Can Guo,Fuyan Wang,Zheng Li,Ming Zhou,Bo Xiang,Yong Li,Wei Xiong,Zhaoyang Zeng +21 more
TL;DR: Zhang et al. as discussed by the authors investigated the specific mechanisms underlying the EBV-dependent promotion of PD-L1 expression to induce immune escape and found that EBV miR-BART11 and EBVmiR-bART17-3p upregulate the expression of PDL1 in EBVassociated NPC and GC.