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Xiao Fen Chen
Researcher at Xiamen University
Publications - 25
Citations - 2032
Xiao Fen Chen is an academic researcher from Xiamen University. The author has contributed to research in topics: TREM2 & Microglia. The author has an hindex of 17, co-authored 25 publications receiving 1392 citations. Previous affiliations of Xiao Fen Chen include University of California, Los Angeles & Laboratory of Molecular Biology.
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Journal ArticleDOI
Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)
Yuka Atagi,Chia Chen Liu,Meghan M. Painter,Xiao Fen Chen,Christophe Verbeeck,Honghua Zheng,Xia Li,Rosa Rademakers,Silvia S. Kang,Huaxi Xu,Steven G. Younkin,Pritam Das,John D. Fryer,Guojun Bu,Guojun Bu +14 more
TL;DR: It is demonstrated that apoE-TREM2 interaction in microglia plays critical roles in modulating phagocytosis of apo E-bound apoptotic neurons and establish a critical link between two proteins whose genes are strongly linked to the risk for AD.
Journal ArticleDOI
Soluble TREM2 induces inflammatory responses and enhances microglial survival
Li Zhong,Xiao Fen Chen,Tingting Wang,Zhe Wang,Chunyan Liao,Zongqi Wang,Ruizhi Huang,Daxin Wang,Xinxiu Li,Linbei Wu,Lin Jia,Honghua Zheng,Meghan M. Painter,Yuka Atagi,Chia Chen Liu,Yun-wu Zhang,John D. Fryer,Huaxi Xu,Huaxi Xu,Guojun Bu,Guojun Bu +20 more
TL;DR: It is shown that sTREM2 promotes microglial survival in a PI3K/Akt-dependent manner and stimulates the production of inflammatory cytokines depending on NF-&kgr;B and this study has implications for the pathogenesis of AD and provides insights into targeting sT REM2 pathway for AD therapy.
Journal ArticleDOI
Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model.
Li Zhong,Ying Xu,Rengong Zhuo,Tingting Wang,Kai Wang,Ruizhi Huang,Daxin Wang,Yue Gao,Yifei Zhu,Xuan Sheng,Kai Chen,Na Wang,Lin Zhu,Dan Can,Yuka Marten,Mitsuru Shinohara,Chia Chen Liu,Dan Du,Hao Sun,Lei Wen,Huaxi Xu,Guojun Bu,Xiao Fen Chen +22 more
TL;DR: The role of sTREM2 is studied in a mouse model of Alzheimer’s disease, and it is found it reduces amyloid accumulation and increases the numbers of plaque-associated microglia which correlates with improved behavioural function in the mice.
Journal ArticleDOI
TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway
Honghua Zheng,Lin Jia,Chia Chen Liu,Zhouyi Rong,Li Zhong,Longyu Yang,Xiao Fen Chen,John D. Fryer,Xin Wang,Yun-wu Zhang,Yun-wu Zhang,Huaxi Xu,Huaxi Xu,Guojun Bu,Guojun Bu +14 more
TL;DR: A critical role of TREM2-mediated Wnt/β-catenin pathway in microglial viability is demonstrated and modulating this pathway therapeutically may help to combat the impaired microglia survival and microgliosis associated with AD.
Journal ArticleDOI
Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2).
Li Zhong,Zongqi Wang,Daxin Wang,Zhe Wang,Yuka A. Martens,Linbei Wu,Ying Xu,Kai Wang,Jianguo Li,Ruizhi Huang,Dan Can,Huaxi Xu,Huaxi Xu,Guojun Bu,Guojun Bu,Xiao Fen Chen +15 more
TL;DR: The data establish a critical link between oAβ1–42, a major pathological component of AD, and TREM2, a strong genetic risk factor for AD expressed in microglia, and suggest that such interaction contributes to the pathogenic events in AD by modulating microglial responses.