M
Mitsuru Shinohara
Researcher at Mayo Clinic
Publications - 52
Citations - 3598
Mitsuru Shinohara is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Apolipoprotein E & Alzheimer's disease. The author has an hindex of 29, co-authored 49 publications receiving 2718 citations. Previous affiliations of Mitsuru Shinohara include Osaka University.
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Journal ArticleDOI
Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetes.
Shuko Takeda,Naoyuki Sato,Kozue Uchio-Yamada,Kyoko Sawada,Takanori Kunieda,Daisuke Takeuchi,Hitomi Kurinami,Mitsuru Shinohara,Hiromi Rakugi,Ryuichi Morishita +9 more
TL;DR: Alzheimer mouse models with early onset of cognitive dysfunction are created that reflect the pathologic conditions of both diabetes mellitus and Alzheimer disease and could provide insights into this intensely debated association.
Journal ArticleDOI
C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins
Yong Jie Zhang,Tania F. Gendron,Jonathan C. Grima,Hiroki Sasaguri,Karen Jansen-West,Ya Fei Xu,Rebecca B. Katzman,Jennifer Gass,Melissa E. Murray,Mitsuru Shinohara,Wen Lang Lin,Aliesha Garrett,Jeannette N. Stankowski,Lillian M. Daughrity,Jimei Tong,Emilie A. Perkerson,Mei Yue,Jeannie Chew,Monica Castanedes-Casey,Aishe Kurti,Zizhao S. Wang,Amanda M. Liesinger,Jeremy D. Baker,Jie Jiang,Clotilde Lagier-Tourenne,Dieter Edbauer,Dieter Edbauer,Don W. Cleveland,Rosa Rademakers,Kevin B. Boylan,Guojun Bu,Christopher D. Link,Chad A. Dickey,Jeffrey D. Rothstein,Dennis W. Dickson,John D. Fryer,Leonard Petrucelli +36 more
TL;DR: It is demonstrated that sequestration and impairment of nuclear HR23 and nucleocytoplasmic transport proteins is an outcome of, and a contributor to, poly(GA) pathology.
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Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model.
Li Zhong,Ying Xu,Rengong Zhuo,Tingting Wang,Kai Wang,Ruizhi Huang,Daxin Wang,Yue Gao,Yifei Zhu,Xuan Sheng,Kai Chen,Na Wang,Lin Zhu,Dan Can,Yuka Marten,Mitsuru Shinohara,Chia Chen Liu,Dan Du,Hao Sun,Lei Wen,Huaxi Xu,Guojun Bu,Xiao Fen Chen +22 more
TL;DR: The role of sTREM2 is studied in a mouse model of Alzheimer’s disease, and it is found it reduces amyloid accumulation and increases the numbers of plaque-associated microglia which correlates with improved behavioural function in the mice.
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Neuronal Clearance of Amyloid-β by Endocytic Receptor LRP1
Takahisa Kanekiyo,John R. Cirrito,Chia Chen Liu,Chia Chen Liu,Mitsuru Shinohara,Jie Li,Dorothy R. Schuler,Motoko Shinohara,David M. Holtzman,Guojun Bu,Guojun Bu +10 more
TL;DR: It is shown that receptor-mediated endocytosis in neurons by the low-density lipoprotein receptor-related protein 1 (LRP1) plays a critical role in brain Aβ clearance and indicates that neurons not only produce but also clear Aβ.
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LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-β.
Takahisa Kanekiyo,Chia Chen Liu,Chia Chen Liu,Mitsuru Shinohara,Jie Li,Jie Li,Guojun Bu,Guojun Bu +7 more
TL;DR: It is demonstrated that Aβ can be cleared locally in the cerebrovasculature by an LRP1-dependent endocytic pathway in smooth muscle cells and a disturbance of this pathway contributes to Aβ accumulation.