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Yun-wu Zhang
Researcher at Discovery Institute
Publications - 21
Citations - 1282
Yun-wu Zhang is an academic researcher from Discovery Institute. The author has contributed to research in topics: Presenilin & Amyloid precursor protein. The author has an hindex of 15, co-authored 21 publications receiving 1146 citations. Previous affiliations of Yun-wu Zhang include Sanford-Burnham Institute for Medical Research & Xiamen University.
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Journal ArticleDOI
TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway
Honghua Zheng,Lin Jia,Chia Chen Liu,Zhouyi Rong,Li Zhong,Longyu Yang,Xiao Fen Chen,John D. Fryer,Xin Wang,Yun-wu Zhang,Yun-wu Zhang,Huaxi Xu,Huaxi Xu,Guojun Bu,Guojun Bu +14 more
TL;DR: A critical role of TREM2-mediated Wnt/β-catenin pathway in microglial viability is demonstrated and modulating this pathway therapeutically may help to combat the impaired microglia survival and microgliosis associated with AD.
Journal ArticleDOI
Pathological and physiological functions of presenilins.
TL;DR: The biology of PS1, its role in γ-secretase activity, and recent developments in the cell biology ofPS1 with respect to Alzheimer's disease pathogenesis are discussed.
Journal ArticleDOI
Presenilin/γ-secretase-dependent processing of β-amyloid precursor protein regulates EGF receptor expression
Yun-wu Zhang,Ruishan Wang,Ruishan Wang,Qiang Liu,Han Zhang,Han Zhang,Francesca-Fang Liao,Huaxi Xu,Huaxi Xu +8 more
TL;DR: It is demonstrated that the levels of PS and EGFR in the skin tumors of PS1+/−/ PS2−/− mice and the brains ofPS1/2 conditional double knockout mice are inversely correlated.
Journal ArticleDOI
Nicastrin Is Critical for Stability and Trafficking but Not Association of Other Presenilin/γ-Secretase Components
Yun-wu Zhang,Wenjie Luo,Hong Wang,Ping Lin,Kulandaivelu S. Vetrivel,Francesca-Fang Liao,Feng Li,Philip C. Wong,Marilyn G. Farquhar,Gopal Thinakaran,Huaxi Xu +10 more
TL;DR: A critical role of Nct is demonstrated in the stability and proper intracellular trafficking of other components of the PS1/ γ-secretase complex but not in maintaining the association of PEN-2, APH-1, and full-length PS1.
Journal ArticleDOI
Transcriptional regulation of APH-1A and increased γ-secretase cleavage of APP and Notch by HIF-1 and hypoxia
Ruishan Wang,Ruishan Wang,Yun-wu Zhang,Xian Zhang,Xian Zhang,Runzhong Liu,Xue Zhang,Shuigen Hong,Kun Xia,Jiahui Xia,Zhuohua Zhang,Zhuohua Zhang,Huaxi Xu,Huaxi Xu,Huaxi Xu +14 more
TL;DR: The results demonstrate that APH‐1A expression and the γ‐secretase mediated Aβ and Notch NICD generation are regulated by HIF‐1, and the specific control of APH •1Aexpression may imply physiological functions uniquely assigned to APH•1A.