G
Gary A. Koretzky
Researcher at University of Pennsylvania
Publications - 244
Citations - 24910
Gary A. Koretzky is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Signal transduction & T cell. The author has an hindex of 58, co-authored 238 publications receiving 23845 citations. Previous affiliations of Gary A. Koretzky include Veterans Health Administration & Howard Hughes Medical Institute.
Papers
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Journal ArticleDOI
Cpg motifs in bacterial dna trigger direct b-cell activation
Arthur M. Krieg,Ae-Kyung Yi,Sara Matson,Thomas J. Waldschmidt,Gail A. Bishop,Gail A. Bishop,Rebecca M. Teasdale,Gary A. Koretzky,Dennis M. Klinman +8 more
TL;DR: The potent immune activation by CpG oligon nucleotides has impli-cations for the design and interpretation of studies using 'antisense' oligonucleotides and points to possible new applications as adjuvants.
Journal ArticleDOI
T cell activation.
TL;DR: This year marks the 25th anniversary of the first Annual Review of Immunology article to describe features of the T cell antigen receptor (TCR), with a description of the current state of the understanding of TCR signaling and a summary of recent findings.
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CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling
Junko Irie-Sasaki,Junko Irie-Sasaki,Takehiko Sasaki,Takehiko Sasaki,Wataru Matsumoto,Anne Opavsky,Mary Cheng,G. Grant Welstead,Emily K. Griffiths,Connie M. Krawczyk,Christopher D. Richardson,Karen Aitken,Norman N. Iscove,Gary A. Koretzky,Pauline Johnson,Peter Liu,David M. Rothstein,Josef M. Penninger,Josef M. Penninger +18 more
TL;DR: Functionally, CD45 negatively regulates interleukin-3-mediated cellular proliferation, erythropoietin-dependent haematopoieisis and antiviral responses in vitro and in vivo.
Journal ArticleDOI
Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway
TL;DR: Although stimulation of the TCR failed to generate Ptdlns-derived second messengers, there was normal activity of the PtdIns pathway when human muscarinic receptor type 1 was stimulated, despite the absence of CD45, indicating that CD45 influences a cellular component that is essential for effective coupling of theTCR to the PTDIns second messenger pathway.
Journal ArticleDOI
Platelets regulate lymphatic vascular development through CLEC-2–SLP-76 signaling
Cara C. Bertozzi,Alec A. Schmaier,Patricia Mericko,Paul R. Hess,Zhiying Zou,Mei Chen,C. Chen,Bin Xu,Min Min Lu,Diane Zhou,Eric Sebzda,Matthew T. Santore,Demetri J. Merianos,Matthias Stadtfeld,Alan W. Flake,Thomas Graf,Radek C. Skoda,Jonathan S. Maltzman,Gary A. Koretzky,Mark L. Kahn +19 more
TL;DR: It is demonstrated that platelets regulate lymphatic vascular development by directly interacting with lymphatic endothelial cells through C-type lectin-like receptor 2 (CLEC-2) receptors, identifying platelets as the cell type in which SLP-76 signaling is required to regulate lymphatics vascular development.