J
Jonathan S. Maltzman
Researcher at Stanford University
Publications - 82
Citations - 3469
Jonathan S. Maltzman is an academic researcher from Stanford University. The author has contributed to research in topics: Cytotoxic T cell & T-cell receptor. The author has an hindex of 23, co-authored 67 publications receiving 3072 citations. Previous affiliations of Jonathan S. Maltzman include University of Pennsylvania & VA Palo Alto Healthcare System.
Papers
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Journal ArticleDOI
T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse
Amy E. Moran,Keli L. Holzapfel,Yan Xing,Nicole R. Cunningham,Jonathan S. Maltzman,Jennifer A. Punt,Kristin A. Hogquist +6 more
TL;DR: Generation of a Nur77 reporter mouse is used to demonstrate TCR signal strength during thymic selection and peripheral maintenance of conventional and nonconventional T cell subsets and presents a novel tool for studying antigen receptor activation in vivo.
Journal ArticleDOI
Platelets regulate lymphatic vascular development through CLEC-2–SLP-76 signaling
Cara C. Bertozzi,Alec A. Schmaier,Patricia Mericko,Paul R. Hess,Zhiying Zou,Mei Chen,C. Chen,Bin Xu,Min Min Lu,Diane Zhou,Eric Sebzda,Matthew T. Santore,Demetri J. Merianos,Matthias Stadtfeld,Alan W. Flake,Thomas Graf,Radek C. Skoda,Jonathan S. Maltzman,Gary A. Koretzky,Mark L. Kahn +19 more
TL;DR: It is demonstrated that platelets regulate lymphatic vascular development by directly interacting with lymphatic endothelial cells through C-type lectin-like receptor 2 (CLEC-2) receptors, identifying platelets as the cell type in which SLP-76 signaling is required to regulate lymphatics vascular development.
Journal ArticleDOI
Azathioprine: old drug, new actions
TL;DR: A knowledge of the biochemical loci of action of 6-MP in the inhibition of nucleic acid synthesis is not sufficient to explain the effects of the thiopurines on the immune system.
Journal ArticleDOI
Enhanced T cell responses due to diacylglycerol kinase ζ deficiency
Xiao-Ping Zhong,Ehmonie A. Hainey,Benjamin A. Olenchock,Martha S. Jordan,Jonathan S. Maltzman,Kim E. Nichols,Hao Shen,Gary A. Koretzky +7 more
TL;DR: It is shown that DGKζ-deficient T cells are hyperresponsive to TCR stimulation both ex vivo and in vivo, and these results demonstrate the importance of DGK ζ as a physiological negative regulator of TCR signaling and T cell activation.
Journal ArticleDOI
An obligate cell-intrinsic function for CD28 in Tregs
Ruan Zhang,Alexandria Huynh,Gregory Whitcher,Jihoon Chang,Jonathan S. Maltzman,Laurence A. Turka +5 more
TL;DR: Clear postmaturational roles for CD28 are demonstrated in FOXP3+ Tregs and mechanisms which are believed to be novel to explain how interruption of CD28-ligand interactions may enhance immune responses independent of effects on thymic development or on other cell types are provided.