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Xiaodong Fang
Researcher at University of Pennsylvania
Publications - 8
Citations - 1961
Xiaodong Fang is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Actin & Cleavage furrow ingression. The author has an hindex of 7, co-authored 7 publications receiving 1720 citations. Previous affiliations of Xiaodong Fang include Stanford University.
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Journal ArticleDOI
Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS
Andrew Elden,Hyung-Jun Kim,Michael P. Hart,Alice Chen-Plotkin,Brian S. Johnson,Xiaodong Fang,Maria Armakola,Felix Geser,Robert W. Greene,Min Min Lu,Arun Padmanabhan,Dana Clay-Falcone,Leo McCluskey,Lauren Elman,Denise Juhr,Peter J. Gruber,Udo Rüb,Georg Auburger,John Q. Trojanowski,Virginia M.-Y. Lee,Vivianna M. Van Deerlin,Nancy M. Bonini,Aaron D. Gitler +22 more
TL;DR: It is shown that ataxin 2 (ATXN2), a polyglutamine (polyQ) protein mutated in spinocerebellar ataxia type 2, is a potent modifier of TDP-43 toxicity in animal and cellular models.
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Molecular Determinants and Genetic Modifiers of Aggregation and Toxicity for the ALS Disease Protein FUS/TLS
Zhihui Sun,Zamia Diaz,Xiaodong Fang,Michael P. Hart,Alessandra Chesi,James Shorter,Aaron D. Gitler +6 more
TL;DR: A combination of yeast genetics and protein biochemistry define how the fused in sarcoma (FUS) protein might contribute to Lou Gehrig's disease.
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Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models
Maria Armakola,Matthew J. Higgins,Matthew D. Figley,Sami J. Barmada,Sami J. Barmada,Emily A. Scarborough,Zamia Diaz,Xiaodong Fang,James Shorter,Nevan J. Krogan,Nevan J. Krogan,Nevan J. Krogan,Steven Finkbeiner,Steven Finkbeiner,Robert V. Farese,Robert V. Farese,Aaron D. Gitler,Aaron D. Gitler +17 more
TL;DR: It is shown that, in the absence of Dbr1 enzymatic activity, intronic lariats accumulate in the cytoplasm and likely act as decoys to sequester TDP-43, preventing it from interfering with essential cellular RNAs and RNA-binding proteins.
Journal ArticleDOI
Biphasic targeting and cleavage furrow ingression directed by the tail of a myosin II
Xiaodong Fang,Jianying Luo,Ryuichi Nishihama,Carsten Wloka,Carsten Wloka,Christopher Dravis,Mirko Travaglia,Masayuki Iwase,Elizabeth A. Vallen,Erfei Bi +9 more
TL;DR: The tail of yeast myosin II is localized to the division site by two distinct molecular pathways and sufficient for promoting actomyosin ring assembly, furrow ingression, and guidance in ECM remodeling.
Journal ArticleDOI
Immobile myosin-II plays a scaffolding role during cytokinesis in budding yeast
TL;DR: Myo1 becomes immobile and acts as a scaffold for proteins involved in septum formation and coordination with the actomyosin ring during yeast cytokinesis.