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Xiaohua Jiang
Researcher at Temple University
Publications - 71
Citations - 3457
Xiaohua Jiang is an academic researcher from Temple University. The author has contributed to research in topics: Inflammation & Proinflammatory cytokine. The author has an hindex of 28, co-authored 56 publications receiving 2565 citations. Previous affiliations of Xiaohua Jiang include Albert Einstein College of Medicine & Baylor College of Medicine.
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Journal ArticleDOI
IL-35 is a novel responsive anti-inflammatory cytokine--a new system of categorizing anti-inflammatory cytokines.
Xinyuan Li,Jietang Mai,Anthony Virtue,Ying Yin,Ren Gong,Xiaojin Sha,Stefanie Gutchigian,Andrew Frisch,Imani Hodge,Xiaohua Jiang,Hong Wang,Xiaofeng Yang +11 more
TL;DR: In-depth analyses of molecular events that regulate the production of IL-35 as well as the new categorization system of anti-inflammatory cytokines are important for the design of new strategies of immune therapies.
Journal ArticleDOI
Caspase-1 Inflammasome Activation Mediates Homocysteine-Induced Pyrop-Apoptosis in Endothelial Cells
Hang Xi,Yuling Zhang,Yanjie Xu,William Y. Yang,Xiaohua Jiang,Xiaojin Sha,Xiaoshu Cheng,Jingfeng Wang,Xuebin Qin,Jun Yu,Yong Ji,Xiaofeng Yang,Hong Wang +12 more
TL;DR: A novel flow-cytometric gating method was established to define pyrotosis (Annexin V(-)/Propidium iodide(+) and termed caspase-1 responsive pyroptosis and apoptosis as pyrop-apoptosis.
Journal ArticleDOI
Hyperhomocysteinemia accelerates atherosclerosis in cystathionine β-synthase and apolipoprotein E double knock-out mice with and without dietary perturbation
Hong Wang,Xiaohua Jiang,Fan Yang,John W. Gaubatz,Lang Ma,Mark J. Magera,Xiaofeng Yang,Peter B. Berger,William Durante,Henry J. Pownall,Andrew I. Schafer +10 more
TL;DR: The results suggest that isolated hyperhomocysteinemia is atherogenic and alters hepatic and macrophage lipoprotein metabolism, in part, by enhancing uptake of modified LDL.
Journal ArticleDOI
Hyperhomocysteinemia Decreases Circulating High-Density Lipoprotein by Inhibiting Apolipoprotein A-I Protein Synthesis and Enhancing HDL Cholesterol Clearance
Dan Liao,Hongmei Tan,Rutai Hui,Zhaohui Li,Xiaohua Jiang,John W. Gaubatz,Fan Yang,William Durante,Lawrence Chan,Andrew I. Schafer,Henry J. Pownall,Xiao-feng Yang,Xiao-feng Yang,Xiao-feng Yang,Hong Wang,Hong Wang,Hong Wang +16 more
TL;DR: Findings indicate that HHcy inhibits reverse cholesterol transport by reducing circulating HDL via inhibiting apoA-I protein synthesis and enhancing HDL-C clearance.
Journal ArticleDOI
Inflammasomes are differentially expressed in cardiovascular and other tissues.
TL;DR: The original model of three-tier expression of inflammasomes would suggest a new concept of tissue inflammation privilege, and provides an insight to the differences among tissues in initiating acute inflammation in response to stimuli.