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Xiaohua Jiang
Researcher at Temple University
Publications - 71
Citations - 3457
Xiaohua Jiang is an academic researcher from Temple University. The author has contributed to research in topics: Inflammation & Proinflammatory cytokine. The author has an hindex of 28, co-authored 56 publications receiving 2565 citations. Previous affiliations of Xiaohua Jiang include Albert Einstein College of Medicine & Baylor College of Medicine.
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Journal ArticleDOI
Hyperhomocysteinemia Potentiates Hyperglycemia-induced Inflammatory Monocyte Differentiation and Atherosclerosis
Pu Fang,Daqing Zhang,Zhongjian Cheng,Chenghui Yan,Xiaohua Jiang,Warren D. Kruger,Shu Meng,Erland Arning,Teodoro Bottiglieri,Eric T. Choi,Yaling Han,Xiaofeng Yang,Hong Wang +12 more
TL;DR: It is demonstrated that HHcy and HG accelerated atherosclerosis and increased lesion monocytes and macrophages and further increased inflammatory MC and MØ levels in peripheral tissues and HHcy-lowering reversed circulating mononuclear cells, MC, and inflammatoryMC and MC-derived M Ø levels.
Journal ArticleDOI
Hyperhomocysteinemia impairs endothelium-derived hyperpolarizing factor–mediated vasorelaxation in transgenic cystathionine beta synthase–deficient mice
Zhongjian Cheng,Xiaohua Jiang,Warren D. Kruger,Domenico Praticò,Sapna Gupta,Karthik Mallilankaraman,Muniswamy Madesh,Andrew I. Schafer,William Durante,Xiaofeng Yang,Hong Wang +10 more
TL;DR: The results suggest that HHcy impairs EDHF relaxation in SMAs by inhibiting SK/IK activities via oxidation- and tyrosine nitration-related mechanisms.
Journal ArticleDOI
Hyperhomocysteinemia and Hyperglycemia Induce and Potentiate Endothelial Dysfunction via μ-Calpain Activation
Zhongjian Cheng,Xiaohua Jiang,Meghana Pansuria,Pu Fang,Jietang Mai,Karthik Mallilankaraman,Rajesh Kumar Gandhirajan,Satoru Eguchi,Rosario Scalia,Muniswamy Madesh,Xiaofeng Yang,Hong Wang +11 more
TL;DR: HHcy potentiated HG-suppressed nitric oxide production and eNOS activity in HAECs, which were prevented by calpain inhibitors or μ-calpsiRNA and adenoviral transduced dominant negative protein kinase C (PKC)β2 inHAECs.
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IL-35 (Interleukin-35) Suppresses Endothelial Cell Activation by Inhibiting Mitochondrial Reactive Oxygen Species-Mediated Site-Specific Acetylation of H3K14 (Histone 3 Lysine 14)
Xinyuan Li,Ying Shao,Xiaojin Sha,Pu Fang,Yin-Ming Kuo,Andrew J. Andrews,Ya-Feng Li,William Y. Yang,Massimo Maddaloni,David W. Pascual,Jin Jun Luo,Xiaohua Jiang,Hong Wang,Xiaofeng Yang +13 more
TL;DR: IL-35 is induced during atherosclerosis development and inhibits mitochondrial reactive oxygen species-H3K14 acetylation-AP-1–mediated EC activation and suppresses atherosclerotic lesion development in ApoE knockout mice.
Journal ArticleDOI
Hyperhomocysteinemia inhibits post-injury reendothelialization in mice
Hongmei Tan,Xiaohua Jiang,Xiaohua Jiang,Fan Yang,Fan Yang,Zhaohui Li,Zhaohui Li,Dan Liao,Dan Liao,JoAnn Trial,Mark J. Magera,William Durante,William Durante,Xiaofeng Yang,Hong Wang,Hong Wang +15 more
TL;DR: The capacity of Hcy to inhibit proliferation and migration of EC may be responsible for impaired reendothelialization and contribute to arteriosclerosis in HHcy and a convenient and accurate mouse model of carotid injury is established.