Xiaoxi Zhuang

TL;DR: Dopaminergic neurons derived from patients with idiopathic and familial PD are studied to identify a time-dependent pathological cascade beginning with mitochondrial oxidant stress leading to oxidized dopamine accumulation and ultimately resulting in reduced glucocerebrosidase enzymatic activity, lysosomal dysfunction, and α-synuclein accumulation.

TL;DR: It is shown that m6A depletion by Mettl14 knockout in embryonic mouse brains prolongs the cell cycle of radial glia cells and extends cortical neurogenesis into postnatal stages and uncovers previously unappreciated transcriptional prepatterning in cortical neural stem cells.

TL;DR: Results indicate that chronically elevated extracellular dopamine facilitates “wanting” and learning of an incentive motivation task for a sweet reward, but elevated dopamine does not increase “liking” reactions to the hedonic impact of sweet tastes.

TL;DR: In this article, the link between severity of COPD, oxidative stress, and NRF2-dependent antioxidant levels in the peripheral lung tissue of patients with COPD was determined.

TL;DR: It is shown that Parkin, PINK1, and DJ-1 formed a complex to promote ubiquitination and degradation of Parkin substrates, including Parkin itself and Synphilin-1 in neuroblastoma cells and human brain lysates and suggests that their PD-pathogenic mutations impair E3 ligase activity of the complex, which may constitute a mechanism underlying PD pathogenesis.