J
Jessie Githanga
Researcher at University of Nairobi
Publications - 36
Citations - 1344
Jessie Githanga is an academic researcher from University of Nairobi. The author has contributed to research in topics: Allele & Population. The author has an hindex of 13, co-authored 32 publications receiving 1242 citations. Previous affiliations of Jessie Githanga include Kenyatta National Hospital & Kenyatta University.
Papers
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Journal ArticleDOI
MDR1 pharmacogenetics: frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity.
Margaret-Mary Ameyaw,Fernando Regateiro,Tao Li,Xiehe Liu,Mohammed Tariq,Abeer Mobarek,Nadia Thornton,Gbolahan Folayan,Jessie Githanga,A. A. Indalo,David Ofori-Adjei,David A. Price-Evans,Howard L. McLeod +12 more
TL;DR: The high frequency of the C allele in the African group implies overexpression of PGP and may have important therapeutic and prognostic implications for use of P GP dependent drugs in individuals of African origin.
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Ethnic differences in thiopurine methyltransferase pharmacogenetics: evidence for allele specificity in Caucasian and Kenyan individuals
Howard L. McLeod,Stuart C. Pritchard,Jessie Githanga,A. A. Indalo,Margaret-Mary Ameyaw,Robert H. Powrie,L. Booth,Elaina Susan Renata Collie-Duguid +7 more
TL;DR: In this paper, the authors determined the frequency of common TPMT variant alleles in 101 Kenyan individuals and 199 Caucasians and confirmed ethnic differences in the predominant mutant allele in the Caucasian individuals.
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Novel thymidylate synthase enhancer region alleles in African populations.
Sharon Marsh,Margaret M. Ameyaw,Margaret M. Ameyaw,Jessie Githanga,A. A. Indalo,David Ofori-Adjei,Howard L. McLeod,Howard L. McLeod +7 more
TL;DR: Assessment of genotype and allele frequencies of the TS polymorphism in 640 African and Caucasian subjects suggests the influence of multiple selection pressures within individual populations, while the common alleles are relatively stable.
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The different epidemiologic subtypes of Burkitt lymphoma share a homogenous micro RNA profile distinct from diffuse large B-cell lymphoma.
Dido Lenze,Lorenzo Leoncini,Michael Hummel,Stefano Volinia,Chang Gong Liu,Teresa Amato,G De Falco,Jessie Githanga,Heike Horn,Joshua Nyagol,German Ott,Jeffrey J.T. Palatini,Michael Pfreundschuh,Emily A Rogena,Andreas Rosenwald,Reiner Siebert,Carlo Croce,Harald Stein +17 more
TL;DR: In this paper, the miRNA profiles of sporadic Burkitt lymphoma (sBL), endemic and human immunodeficiency virus-associated (HIV-BL) were generated from 18 eBL, 31 sBL and 15 HIV-BL cases.
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Lymphomas in sub-Saharan Africa – what can we learn and how can we help in improving diagnosis, managing patients and fostering translational research?
Kikkeri N. Naresh,Martine Raphael,Leona W. Ayers,Nina Hurwitz,Valeria Calbi,Emily A Rogena,Shahin Sayed,Omar Sherman,Hazem A. H. Ibrahim,Hazem A. H. Ibrahim,Stefano Lazzi,Vasileios Mourmouras,Patricia Rince,Jessie Githanga,Bessie Byakika,Emma Moshi,Muheez A. Durosinmi,Babatunde J. Olasode,Olayiwola A. Oluwasola,Effiong E. Akang,Yetunde Aken'ova,Melissa Adde,Ian Magrath,Lorenzo Leoncini +23 more
TL;DR: The results on the diagnostic accuracy and on the distribution of different lymphoma subsets in sub‐Saharan Africa were based on a review undertaken by a team of lymphoma experts on 159 fine needle aspirate samples and 467 histological samples during their visit to selected sub-Saharan African centres is presented.