Showing papers in "Oral Oncology in 2010"
TL;DR: The different diagnosis should be established with other oral malignant diseases such as lymphomas, sarcomas and metastasis, which have rapid growth rates as opposed to the typical OSCC.
389 citations
TL;DR: Prevention strategies for this high risk group should include offering smoking cessation and other risk reduction measures, and the highest prevalence at 5years is seen in Western Europe.
297 citations
TL;DR: The methods by which the behavior and prognosis of OTSCC has been studied, the prognostics markers, and the relevance and future direction of prognostic studies are examined are examined.
217 citations
TL;DR: This paper will be a review defect classification, goals of reconstruction, the various donor sites, dental rehabilitation, new advances, and persistent problems in oro-mandibular reconstruction.
215 citations
TL;DR: It is actually unknown whether removal of any oral of oropharyngeal leukoplakia/erythroplakia, if feasible, irrespective of the presence or absence of dysplasia truly prevents the possible development of a squamous cell carcinoma.
214 citations
TL;DR: Routine collection of comorbidity data should be integrated with tumor-specific staging systems in order to develop better instruments for prognostication, as well as comparing results of different treatment regimens and institutions.
198 citations
TL;DR: The recently identified biomarkers from saliva for OSCC are reviewed and the potential biomarkers that have been demonstrated to associate with the malignant OSCC may be used for salivary screening for high-risk patients are suggested.
162 citations
TL;DR: Since the introduction of Marx's protocol, there have been advances in surgical techniques, as well as in imaging techniques, which have significantly impacted on the diagnosis and management of ORN.
145 citations
TL;DR: It is suggested that miR-24 is involved in the regulation of OSCC growth and that the miR -24's level in plasma may be validatable as a tumor marker for OSCC patients.
143 citations
TL;DR: Taste dysfunction in cancer patients impacts quality of life and impairs oral intake, which may have broader implications consisting of weight loss and nutritional compromise.
131 citations
TL;DR: Investigation in working-age head and neck cancer survivors before and after treatment in relation to sociodemographic and clinical factors, health related quality of life, and emotional distress found anxiety and oral dysfunction were significantly associated with employment after treatment.
TL;DR: The key element for future management of KCOTs will probably be based on thorough knowledge of the biological basis of this tumor, thereby enabling a more tailored treatment approach.
TL;DR: The results suggest the existence of differential miRNAs with chemosensitivity and chemoresistance between the cisplatin-sensitive and resistant tongue squamous cell carcinoma lines.
TL;DR: The presence of one or both factors (LVP and/or non-T4MI) should be considered as a high-risk condition for locoregional recurrence, and adjuvant therapy is needed in such cases.
TL;DR: Patients with HPV-positive and HPV-negative head and neck squamous cell carcinoma and laboratory biomarkers of HPV exposure for a diagnosis of HPV16-positive HNSCC compared to in situ hybridization, the current gold-standard, showed no change in predictive value.
TL;DR: There is convincing evidence that the detection of p16 protein by immunohistochemistry can be used as a surrogate marker for the elaboration of oncogenic HPV proteins in head and neck cancers.
TL;DR: Transoral robotic hypopharyngectomy by transoral robotic surgery was feasible and ontologically safe technique for the treatment of early hypoph throat cancer and posterior pharyngeal wall cancer.
TL;DR: It is demonstrated that HNSCC-ALDH1(+) cells possess tumor initiating properties, are capable of self-renewal, and express higher levels of Bmi-1 as compared to HNS CC-AL DH1(-) cells, and this results suggest that B mi-1 is a potential target for increasing the sensitivity of H NSCC cancer stem cells to chemoradiotherapy.
TL;DR: Results from the PD, PK and safety pharmacology studies reported here indicate that in situ secretion of hTFF1 by topically administered L. lactis bacteria provides a safe and efficacious therapeutic tool for the prevention and treatment of OM.
TL;DR: The Sydney Swallow Questionnaire is a precise, reliable and valid tool for assessing swallow in this patient group and is able to demonstrate the reliability and validity of the SSQ in HNC patients.
TL;DR: Several oral micro-organisms metabolize alcohol to carcinogenic acetaldehyde thus explaining the association between poor oral hygiene, alcohol consumption and carcinogenesis, and the Mediterranean-type fruit and vegetable rich diet has been shown to reduce the risk of oral cancer.
TL;DR: Subgroup analyses for studies that adjusted for main potential confounding factors (age, sex, and tobacco use) and several further subgroup analyses showed similar results, which suggest the robustness of the results.
TL;DR: This meta-analysis provides more precise evidence of a gross excess of OPC risk for heavy alcohol drinkers and indicates an increased risk for moderate doses, i.e.,
TL;DR: Overall urban incidence of HNC was twice or more that of rural incidence for both males and females and among subsites, highest incidence among males was for larynx and among females for gum and mouth.
TL;DR: Based on the current understanding of ORN pathophysiology, new preventive and therapeutic protocols have been suggested for mild to moderate stages and free tissue surgical transfers is the treatment of choice of severe, extensive and long established ORN.
TL;DR: The literature suggests that limiting the radiation dose to certain structures may result in favourable swallowing outcomes following IMRT for head and neck cancer and well designed, prospective, longitudinal swallowing studies including multidimensional evaluation methods are required to enable a more comprehensive understanding of dysphagia complications.
TL;DR: It was suggested that the presence of tumor cells at or close to the surgical margin increased the risk of local recurrence and the width of the free margin should be included in deciding the necessity for adjuvant radiotherapy.
TL;DR: This is the first pilot study demonstrating that both CEP55 and HELLS mRNA and protein expression positively correlate with pre-malignancy and HNSCC progression and provides strong evidence that CEP 55 and HELLs may be used in conjunction with FOXM1 as a biomarker set for early cancer detection and indicators of malignant conversion and progression.
TL;DR: An overview of the definition of quality of life (QoL), how it is measured, the key issues for patients with respect oral cancer, and comment about the role of the dental multidisciplinary team are provided.
TL;DR: This study demonstrates high prevalence of OPMD, betel-quid chewing with or without tobacco being the major risk factor, and a synergistic effect of chewing and alcohol consumption existed.