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Xiaxin Li
Researcher at Indiana University
Publications - 9
Citations - 1738
Xiaxin Li is an academic researcher from Indiana University. The author has contributed to research in topics: Progenitor cell & Fanconi anemia. The author has an hindex of 9, co-authored 9 publications receiving 1677 citations. Previous affiliations of Xiaxin Li include University of Chicago.
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Journal ArticleDOI
Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist
Hal E. Broxmeyer,Christie M. Orschell,D. Wade Clapp,Giao Hangoc,Scott Cooper,P. Artur Plett,W. Conrad Liles,Xiaxin Li,Barbara Graham-Evans,Timothy B. Campbell,Gary Calandra,Gary Bridger,David C. Dale,Edward F. Srour +13 more
TL;DR: Results support the hypothesis that the CXCL12-CXCR4 axis is involved in marrow retention of HSCs and HPCs, and demonstrate the clinical potential of AMD3100 for HSC mobilization.
Journal ArticleDOI
Stromal cell-derived factor-1/CXCL12 directly enhances survival/antiapoptosis of myeloid progenitor cells through CXCR4 and Gαi proteins and enhances engraftment of competitive, repopulating stem cells
Hal E. Broxmeyer,Lisa L. Kohli,Chang H. Kim,Young Hee Lee,Charlie Mantel,Scott Cooper,Giao Hangoc,Montaser Shaheen,Xiaxin Li,D. Wade Clapp +9 more
TL;DR: SDF‐1/CXCL12 greatly enhanced the engrafting capability of mouse long‐term, marrow‐competitive, repopulating stem cells cultured ex vivo with interleukin‐6 and steel factor for 48 h.
Journal ArticleDOI
Retroviral-mediated expression of recombinant Fancc enhances the repopulating ability of Fancc-/- hematopoietic stem cells and decreases the risk of clonal evolution.
Laura S. Haneline,Xiaxin Li,Samantha L.M. Ciccone,Ping Hong,Yanzhu Yang,Hal E. Broxmeyer,Suk Hee Lee,Attilio Orazi,Edward F. Srour,D. Wade Clapp +9 more
TL;DR: Examination of retroviral-mediated gene transfer of recombinant Fancc (rFancc) and progenitors from patients with myelodysplasia show that gene transfer can enhance HSC repopulating ability and suppresses the tendency for clonal evolution.
Journal ArticleDOI
Fanconi anemia type C and p53 cooperate in apoptosis and tumorigenesis
Brian Freie,Xiaxin Li,Samantha L.M. Ciccone,Kathy Nawa,Scott Cooper,Catherine M. Vogelweid,Laurel Schantz,Laura S. Haneline,Attilio Orazi,Hal E. Broxmeyer,Suk Hee Lee,D. Wade Clapp +11 more
TL;DR: It is demonstrated that p53 and Fancc interact functionally to regulate apoptosis and tumorigenesis in Fancc-deficient cells.
Journal ArticleDOI
Ex vivo culture of Fancc-/- stem/progenitor cells predisposes cells to undergo apoptosis, and surviving stem/progenitor cells display cytogenetic abnormalities and an increased risk of malignancy
Xiaxin Li,Xiaxin Li,Michelle M. Le Beau,Michelle M. Le Beau,Samantha L.M. Ciccone,Samantha L.M. Ciccone,Feng Chun Yang,Feng Chun Yang,Brian Freie,Brian Freie,Shi Chen,Shi Chen,Jin Yuan,Jin Yuan,Ping Hong,Ping Hong,Attilio Orazi,Attilio Orazi,Laura S. Haneline,Laura S. Haneline,D. Wade Clapp +20 more
TL;DR: It is shown that ex vivo culture of Fancc (-/-) bone marrow cells results in a time-dependent increase in apoptosis of primitive Fancc(-/-) progenitor cells in conditions that promote the proliferation of wild-type stem/progenitor cells.