https://bioone.org/journals/harvard-papers-in-botany/volume-13/issue-2/1043-4534-13.2.299/Flora-of-China/10.3100/1043-4534-13.2.299.pdf

Flora of China

The Book of Flowering Trees and Shrubs By Stanley B. Whitehead. Pp. 244 + 63 plates in colour. (London and New York: Frederick Warne and Co., Ltd., 1956.) 15s. net.

Trees and Shrubs

Structural diversity, bioactivities, and biosynthesis of natural diterpenoid alkaloids

This review covers the isolation and structure determination of limonoids reported during 2014–2016 (with 363 new compounds in 68 papers), together with the relevant biological activities and source organisms. Furthermore, the total synthesis and structural modifications of limonoids and their analogs regarding the bioactivities reported during 2011–2016 have also been summarised.

/pdf/recent-progress-in-the-chemistry-and-biology-of-limonoids-39uzi9wxwe.pdf

Recent progress in the chemistry and biology of limonoids

Spirotrichilins A and B: Two Rearranged Spirocyclic Limonoids from Trichilia connaroides.

Fourteen new limonoids, munronins A-N (1-14), and eight known limonoids (15-22) were isolated from the whole plants of Munronia henryi. The structures of the new compounds were elucidated by 2D NMR spectroscopy and mass spectrometry, and the structure of 8 was confirmed by single-crystal X-ray diffraction analysis. Compound 1 represents the first limonoid found with a novel 7-oxabicyclo[2.2.1]heptane moiety produced by incorporating C-11 and C-14 via an oxygen atom. All compounds were evaluated for their anti-tobacco mosaic virus (TMV) activity and in vitro cytotoxicity against the human cancer HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines. Among them, compounds 2, 8, 9, 10, 11, 12, 18, and 20 showed significant anti-TMV activity, with IC50 values in the range 19.6-44.4 mu g/mL. Compounds 1 and 18 exhibited cytotoxic effects for all five cancer cell lines, with IC50 values between 0.4 and 4.8 mu M.

Xin-Ying Mao

Papers

Bioactive Limonoid Constituents of Munronia henryi.

Diterpene alkaloids and diterpenes from Spiraea japonica and their anti-tobacco mosaic virus activity